ArticleNature communications2018
Diffusion-limited reactions in dynamic heterogeneous media.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 155 citations in OpenAlex.
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.Magnetic resonance letters · 2026Article
- Single-trajectory Bayesian modeling reveals multi-state diffusion of the MSH sliding clamp.NPJ systems biology and applications · 2026Article
- Protein codes and mobility together shape cellular function and disease.Trends in biochemical sciences · 2026Review
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.bioRxiv : the preprint server for biology · 2025Article
- Time-dependent diffusion in one-dimensional disordered media decorated by permeable membranes: Theoretical findings backed by simulations and a new disorder class.Physics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Article
- Efficient Estimates of Surface Diffusion Parameters for Spatio-Temporally Resolved Virus Replication Dynamics.International journal of molecular sciences · 2024Article
- Particle-environment interactions in arbitrary dimensions: A unifying analytic framework to model diffusion with inert spatial heterogeneities.Physical review research · 2023Article
- Diffusion-Controlled Reactions: An Overview.Molecules (Basel, Switzerland) · 2023Review
- Endoplasmic reticulum network heterogeneity guides diffusive transport and kinetics.Biophysical journal · 2023Article
- Heterogeneous biological membranes regulate protein partitioning via fluctuating diffusivity.PNAS nexus · 2023Article
- Fickian yet non-Gaussian diffusion of a quasi-2D colloidal system in an optical speckle field: experiment and simulations.Scientific reports · 2023Article
- Population heterogeneity in the fractional master equation, ensemble self-reinforcement, and strong memory effects.Physical review. E · 2023Article
- Evolutionary divergence of anaphase spindle mechanics in nematode embryos constrained by antagonistic pulling and viscous forces.Molecular biology of the cell · 2022Article
- Real-space imaging of nanoparticle transport and interaction dynamics by graphene liquid cell TEM.Science advances · 2021Article
- Objective comparison of methods to decode anomalous diffusion.Nature communications · 2021Article
- Detecting Transient Trapping from a Single Trajectory: A Structural Approach.Entropy (Basel, Switzerland) · 2021Article
- From diffusion in compartmentalized media to non-Gaussian random walks.Scientific reports · 2021Article
- Article
- Heterogeneities Shape Passive Intracellular Transport.Biophysical journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passage time to a reaction event. Here, we investigate the effect of these dynamic spatiotemporal heterogeneities onto diffusion-limited reactions. We describe a general mathematical framework to translate many results for ordinary homogeneous Brownian motion to heterogeneous diffusion. In particular, we derive the probability density of the first-passage time to a reaction event and show how the dynamic disorder broadens the distribution and increases the likelihood of both short and long trajectories to reactive targets. While the disorder slows down reaction kinetics on average, its dynamic character is beneficial for a faster search and realization of an individual reaction event triggered by a single molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.