Evidence map›Paper›PMID 30352993›Full record

ArticleTranslational psychiatry2018

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development.

Donna L McPhie, Ralda Nehme, Caitlin Ravichandran, Suzann M Babb, Sulagna Dia Ghosh, Alexandra Staskus, Amy Kalinowski, Rupinderjit Kaur, Panagiotis Douvaras, Fei Du and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. IncreasingBiological psychiatry global open science · 2025
    Article
  3. Repurposing medications to prevent psychosis.Npj mental health research · 2025
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Donna L McPhieHarvard Medical School, Boston, MA, USA.
Ralda NehmeStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
Caitlin RavichandranHarvard Medical School, Boston, MA, USA.
Suzann M BabbHarvard Medical School, Boston, MA, USA.
Sulagna Dia GhoshStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
Alexandra StaskusMcLean Hospital, 115 Mill St., Belmont, MA, 02478, USA.
Amy KalinowskiMcLean Hospital, 115 Mill St., Belmont, MA, 02478, USA.
Rupinderjit KaurMcLean Hospital, 115 Mill St., Belmont, MA, 02478, USA.
Panagiotis DouvarasBlue Rock Therapeutics, Alexandria Center for Life Science, 450 E 29th Street, Suite 504, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0002-4430-997X
Fei DuHarvard Medical School, Boston, MA, USA.
Dost OngurHarvard Medical School, Boston, MA, USA.
Valentina FossatiThe New York Stem Cell Foundation Research Institute, 619 West 54th Street, 3rd Floor, New York, NY, 10019, USA.
Kevin EgganDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
Bruce M CohenHarvard Medical School, Boston, MA, USA. bcohen@mclean.harvard.edu.

Funding

Research and Mentoring on Brain and Peripheral Bioenergetics in SchizophreniaK24MH104449 · NIMH · MCLEAN HOSPITAL · PI ONGUR, DOST · 2015 to 2019
$749k
Oxidative Stress in First Episode Schizophrenia Assessed in vivo Using NAD+ and NADH MeasurementR21MH114020 · NIMH · MCLEAN HOSPITAL · PI DU, FEI · 2017 to 2018
$451k
NIMH NIH HHS K24 MH104449NIMH NIH HHS R21 MH114020
6 · The paper itself

Abstract

Abnormalities of brain connectivity and signal transduction are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function and lower myelination in SZ. Our primary hypothesis was that there would be abnormalities in the number of induced pluripotent stem (iPS) cell-derived OLs from subjects with SZ. Our secondary hypothesis was that these in vitro abnormalities would correlate with measures of white matter (WM) integrity and myelination in the same subjects in vivo, estimated from magnetic resonance imaging. Six healthy control (HC) and six SZ iPS cell lines, derived from skin fibroblasts from well-characterized subjects, were differentiated into OLs. FACS analysis of the oligodendrocyte-specific surface, glycoprotein O4, was performed at three time points of development (days 65, 75, and 85) to quantify the number of late oligodendrocyte progenitor cells (OPCs) and OLs in each line. Significantly fewer O4-positive cells developed from SZ versus HC lines (95% CI 1.0: 8.6, F

Indexed as

AdultBrainCell DifferentiationCell LineFemaleHumansInduced Pluripotent Stem CellsMagnetic Resonance ImagingMaleMiddle AgedMyelin SheathOligodendrocyte Precursor CellsOligodendrogliaSchizophreniaWhite MatterYoung Adult

Identifiers

PMID30352993
PMCPMC6199264

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.