Observational studyThe oncologist2019
Phase Angle and the Diagnosis of Impending Death in Patients with Advanced Cancer: Preliminary Findings.
Observational study in The oncologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Bioelectrical impedance analysis-derived phase angle (PhA) in lung cancer patients: a systematic review.BMC cancer · 2024Pooled it
- Effectiveness of combined nutrition, exercise and psychological interventions in patients with malignancy: A randomized controlled trial.Asia Pacific journal of clinical nutrition · 2026Trial
- Association Between Plasma Brain Natriuretic Peptide and Overall Survival in Patients With Advanced Cancer: Preliminary Findings.Journal of pain and symptom management · 2019Trial
- Perioperative phase angle decline is associated with postoperative sarcopenia in esophageal cancer: a longitudinal cohort study with internal validation.Frontiers in nutrition · 2026Article
- Article
- Use of phase angle as an indicator of overtraining in sport and physical training.Journal of translational medicine · 2024Review
- Methodology for integrated analysis of vector- and spectroscopic bioimpedance methods.Journal of electrical bioimpedance · 2024Article
- Association between Phase Angle and Subjective Perceptions of Health Variables in Cancer Patients.Healthcare (Basel, Switzerland) · 2023Article
- Diagnostic and prognostic utility of phase angle in patients with cancer.Reviews in endocrine & metabolic disorders · 2023Review
- Article
- Association between PhA and Physical Performance Variables in Cancer Patients.International journal of environmental research and public health · 2023Article
- Independent effect of fat-to-muscle mass ratio at bioimpedance analysis on long-term survival in patients receiving surgery for pancreatic cancer.Frontiers in nutrition · 2023Article
- Phase Angle, a Cornerstone of Outcome in Head and Neck Cancer.Nutrients · 2022Article
- Prognostication of the Last Days of Life.Cancer research and treatment · 2022Article
- Article
- Assessment of the Decision-Making Capacity for Clinical Research Participation in Patients With Advanced Cancer in the Last Weeks of Life.Journal of pain and symptom management · 2020Observational
- Collapse of Fluid Balance and Association with Survival in Patients with Advanced Cancer Admitted to a Palliative Care Unit: Preliminary Findings.Journal of palliative medicine · 2020Observational
- Prognostication in advanced cancer: update and directions for future research.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPhase angle is a prognostic factor in patients with months of survival, but its accuracy has not been examined in patients with weeks/days of survival. We determined the association between phase angle and survival in patients with advanced cancer admitted to an acute palliative care unit (APCU). SUBJECTS, MATERIALS, AND
methodsWe prospectively assessed phase angle in consecutive patients with advanced cancer admitted to our APCU. We conducted univariate and multivariate survival analyses adjusting for established prognostic factors. Post hoc subgroup analyses examined patients with and without edema.
resultsAmong 204 patients, the median overall survival was 10 days (95% confidence interval [CI] 8-11 days). Seventy-four (36%) did not have edema. The median phase angle was 3.7° for the entire cohort, 3.9° for the nonedematous subgroup and 3.6° for the edematous subgroup. In univariate analysis, a low phase angle was associated with decreased survival for the entire cohort (≤3° vs. >3°, median survival 7 vs. 10 days,
conclusionPhase angle had limited prognostic utility in unselected APCU patients but was significant in the nonedematous subgroup. Further studies are required to confirm these preliminary findings. IMPLICATIONS FOR PRACTICE: In this prospective study involving 204 patients with advanced cancer, phase angle as measured by bioelectric impedance analysis was a significant predictor of mortality independent of known prognostic factors in patients without edema but not patients with edema. Among patients without edema, a phase angle ≤3° had an accuracy of 86% for 3-day survival, which may inform the diagnosis of impending death and potentially end-of-life decision making.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.