ArticleProceedings of the National Academy of Sciences of the United States of America2018
Evolutionarily conserved
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
52 citing papers in PubMed, 71 citations in OpenAlex.
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- Spatiotemporal Profiling Defines the Epithelial and Mesenchymal Transition Window in Embryonic Lung Morphogenesis.Journal of developmental biology · 2026Article
- Antioxidant Astaxanthin Co-Treatment Protects Zebrafish from Dimethomorph-Induced Cardiovascular Toxicity.International journal of molecular sciences · 2026Article
- Temporal regulation of wnt signaling in alveolar development and regeneration: mechanistic insights and therapeutic advances in chronic lung diseases.Frontiers in cell and developmental biology · 2026Review
- Fzd2 orchestrates canonical and non-canonical Wnt signaling to regulate lung development and fibrosis.Cell communication and signaling : CCS · 2025Article
- HOXA5-driven transcriptional program in lung development.Developmental biology · 2025Article
- Common genetic variation influencing the human lung imaging phenotypes.Nature communications · 2025Article
- The Interplay of Ontogeny and Phylogeny at the Transcriptome Level of the Tetrapod Heart.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development.Cell reports · 2025Article
- Advances in humanoid organoid-based research on inter-organ communications during cardiac organogenesis and cardiovascular diseases.Journal of translational medicine · 2025Review
- Bioinformatic Analysis of WNT Family Proteins.Bioinformatics and biology insights · 2025Article
- PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.Life science alliance · 2024Article
- A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish.PLoS genetics · 2024Article
- Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice.Acta pharmacologica Sinica · 2024Article
- The molecular and cellular choreography of early mammalian lung development.Medical review (2021) · 2024Review
- Cardiopulmonary progenitors facilitate cardiac repair via exosomal transfer of miR-27b-3p targeting the SIK1-CREB1 axis.Cell proliferation · 2024Article
- Distribution-Agnostic Deep Learning Enables Accurate Single-Cell Data Recovery and Transcriptional Regulation Interpretation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 2 countries.
Jeffrey D SteimleDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-1369-9661
Scott A RankinCenter for Stem Cell and Organoid Medicine, Cincinnati Children's Research Foundation, Cincinnati, OH 45229.
Christopher E SlagleDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Jenna BekenyDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Ariel B RydeenDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Sunny Sun-Kin ChanDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455.
Junghun KweonDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Xinan H YangDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Kohta IkegamiDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Rangarajan D NadadurDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Megan RowtonDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Andrew D HoffmannDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
Sonja LazarevicDepartment of Pediatrics, University of Chicago, Chicago, IL 60637.
William ThomasNational Xenopus Resource, Marine Biological Laboratory, Woods Hole, MA 02543.
Erin A T Boyle AndersonDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637.
Marko E HorbNational Xenopus Resource, Marine Biological Laboratory, Woods Hole, MA 02543.
Luis Luna-ZuritaGladstone Institute of Cardiovascular Disease, San Francisco, CA 94158.
Robert K HoLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455.
Michael KybaDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-5579-7534
Bjarke JensenAmsterdam Cardiovascular Sciences, Department of Medical Biology, Amsterdam University Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands.ORCID 0000-0002-7750-8035
Aaron M ZornCenter for Stem Cell and Organoid Medicine, Cincinnati Children's Research Foundation, Cincinnati, OH 45229.
Frank L ConlonDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Ivan P MoskowitzDepartment of Pediatrics, University of Chicago, Chicago, IL 60637; imoskowitz@uchicago.edu.
University of Chicago · USUniversity of Minnesota · USCincinnati Children's Hospital Medical Center · USMarine Biological Laboratory · USUniversity of North Carolina at Chapel Hill · USAmsterdam University Medical Centers · NLGladstone Institutes · US
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MMolecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9MPREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0MProject-3: Modeling EA/TEF in human organoidsP01HD093363 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Wendy K Chung, Paul scot Kingma · 2017 to 2026
$16.2MResource CoreP40OD010997 · OD · MARINE BIOLOGICAL LABORATORY · PI Marko E Horb · 2012 to 2026
$13.1MMULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5MMidwestern Progenitor Cell ConsortiumU01HL100407 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J., KYBA, MICHAEL · 2009 to 2015
$7.8MGenetic and Molecular Analysis of Mutants with Congenital Heart DefectsR01HL092153 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL · 2009 to 2017
$4.5MTraining Program in Developmental BiologyT32HD055164 · NICHD · UNIVERSITY OF CHICAGO · PI Sally Horne-Badovinac, Paschalis Kratsios · 2008 to 2026
$3.6MXenopus models of human disease by targeted genome editingR01HD084409 · NICHD · MARINE BIOLOGICAL LABORATORY · PI HORB, MARKO E · 2015 to 2019
$2.9MMolecular Basis of Liver Development.R01DK070858 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZORN, AARON M · 2007 to 2017
$2.9MCardiac interaction networks as determinants of transcriptional specificityR01HD089275 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, CRISTEA, ILEANA M. · 2017 to 2021
$2.9MNHLBI NIH HHS R01 HL092153NHLBI NIH HHS R01 HL114898NHLBI NIH HHS R01 HL124836NHLBI NIH HHS R01 HL126509NHLBI NIH HHS T32 HL007381NHLBI NIH HHS U01 HL100407NIA NIH HHS R21 AG054770NIA NIH HHS R33 AG054770NICHD NIH HHS P01 HD093363NICHD NIH HHS R01 HD072598NICHD NIH HHS R01 HD084409NICHD NIH HHS R01 HD089275NICHD NIH HHS T32 HD055164NIDDK NIH HHS R01 DK070858NIGMS NIH HHS T32 GM007183NIGMS NIH HHS T32 GM007197NIGMS NIH HHS T32 GM007281NIH HHS P40 OD010997NIH HHS S10 OD018495NLM NIH HHS R21 LM012619
Abstract
Codevelopment of the lungs and heart underlies key evolutionary innovations in the transition to terrestrial life. Cardiac specializations that support pulmonary circulation, including the atrial septum, are generated by second heart field (SHF) cardiopulmonary progenitors (CPPs). It has been presumed that transcription factors required in the SHF for cardiac septation, e.g.,
Indexed as
Evolution, MolecularAnimalsEnhancer Elements, GeneticGene Expression ProfilingHeartLungMiceMice, Mutant StrainsSignal TransductionT-Box Domain ProteinsTranscription, GeneticWnt2 ProteinZebrafishT-Box Domain ProteinsT-box transcription factor 5Wnt2 Proteinheart developmentHedgehog signalinglung developmentTBX5Wnt signaling
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.