ArticleProceedings of the National Academy of Sciences of the United States of America2018
Physical interactions reduce the power of natural selection in growing yeast colonies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The influence of cell morphology on the dynamics and stability of model bacterial communities.PLoS computational biology · 2026Article
- A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape.Nature ecology & evolution · 2026Article
- Biosurfactants direct the evolutionary dynamics of surface-associated microbial systems.Science advances · 2026Article
- Genetically homogeneous sector morphologies emerge from anisotropic colony growth.Physical review. E · 2026Article
- Sensitivity of microbial spatial self-organization to surface friction depends on metabolic interactions.The ISME journal · 2026Article
- Emergent collective alignment gives competitive advantage to longer cells during range expansion.Nature communications · 2025Article
- A dual reporter system for intracellular and extracellular amino acid sensing in budding yeast.Molecular biology of the cell · 2025Article
- Disentangling the feedback loops driving spatial patterning in microbial communities.NPJ biofilms and microbiomes · 2025Review
- Uptake and leakage rates differentially shape community arrangement and composition of microbial consortia.The ISME journal · 2025Article
- Mechanics limits ecological diversity and promotes heterogeneity in confined bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cross-feeding promotes heterogeneity within yeast cell populations.Nature communications · 2024Article
- Evaporation-induced hydrodynamics control plasmid transfer during surface-associated microbial growth.NPJ biofilms and microbiomes · 2023Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Impact of crowding on the diversity of expanding populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations.Nature communications · 2022Article
- Time-Dependent Biosensor Fluorescence as a Measure of Bacterial Arsenic Uptake Kinetics and Its Inhibition by Dissolved Organic Matter.Applied and environmental microbiology · 2022Article
- Stochastic establishment of β-lactam-resistantProceedings. Biological sciences · 2022Article
- Rare and localized events stabilize microbial community composition and patterns of spatial self-organization in a fluctuating environment.The ISME journal · 2022Article
- Population genetics in microchannels.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ecohydrology 2.0.Rendiconti Lincei. Scienze fisiche e naturali · 2022Review
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Authors and funding
3 authors.
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Abstract
Microbial populations often assemble in dense populations in which proliferating individuals exert mechanical forces on the nearby cells. Here, we use yeast strains whose doubling times depend differently on temperature to show that physical interactions among cells affect the competition between different genotypes in growing yeast colonies. Our experiments demonstrate that these physical interactions have two related effects: they cause the prolonged survival of slower-growing strains at the actively-growing frontier of the colony and cause faster-growing strains to increase their frequency more slowly than expected in the absence of physical interactions. These effects also promote the survival of slower-growing strains and the maintenance of genetic diversity in colonies grown in time-varying environments. A continuum model inspired by overdamped hydrodynamics reproduces the experiments and predicts that the strength of natural selection depends on the width of the actively growing layer at the colony frontier. We verify these predictions experimentally. The reduced power of natural selection observed here may favor the maintenance of drug-resistant cells in microbial populations and could explain the apparent neutrality of interclone competition within tumors.
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