Evidence map›Paper›PMID 30352748›Full record

Trial reportClinical nutrition (Edinburgh, Scotland)2019

Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.

Edith Angellotti, David D'Alessio, Bess Dawson-Hughes, Yan Chu, Jason Nelson, Peter Hu, Robert M Cohen, Anastassios G Pittas

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition (Edinburgh, Scotland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01736865 (Vitamin D for Established Type 2 Diabetes), which is not on this map. Cited by 30 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 8 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01736865 phase2 / phase3completednot on this map

Vitamin D for Established Type 2 Diabetes (DDM2)

TypeinterventionalSponsorTufts Medical CenterRan2012 to 2015Enrolled127ConditionsType 2 DiabetesArmsCholecalciferol, Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 8 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  20. Roles of THEM4 in the Akt pathway: a double-edged sword.Journal of Zhejiang University. Science. B · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Edith AngellottiDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, 800 Washington Street, #268, Boston, MA, 02111, USA. Electronic address: eangellotti@tuftsmedicalcenter.org.
David D'AlessioDivision of Endocrinology, Diabetes and Metabolism, Duke University, Durham, NC, 27710, USA. Electronic address: david.d'alessio@duke.edu.
Bess Dawson-HughesDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, 800 Washington Street, #268, Boston, MA, 02111, USA; Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA. Electronic address: bess.dawson-hughes@tufts.edu.
Yan ChuUniversity of Kentucky College of Medicine, Lexington, KY, 40506, USA. Electronic address: ych228@uky.edu.
Jason NelsonPredictive Analytics and Comparative Effectiveness (PACE) Center, Tufts Medical Center, Boston, MA, 02111, USA. Electronic address: jnelson2@tuftsmedicalcenter.org.
Peter HuCornell University, Ithaca, NY, 14850, USA. Electronic address: peterhu15412@gmail.com.
Robert M CohenDivision of Endocrinology, Diabetes & Metabolism, University of Cincinnati College of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, 45267-0547, USA. Electronic address: robert.cohen@uc.edu.
Anastassios G PittasDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, 800 Washington Street, #268, Boston, MA, 02111, USA. Electronic address: apittas@tuftsmedicalcenter.org.
Tufts Medical Center · USCincinnati VA Medical Center · USCornell University · USDuke University · USTufts University · USUniversity of Kentucky · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
TUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCAUL1RR025752 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$17.6M
Vitamin D and Calcium Homeostasis in Relation to Type 2 DiabetesR01DK076092 · NIDDK · TUFTS MEDICAL CENTER · PI PITTAS, ANASTASSIOS G · 2006 to 2015
$4.1M
NCATS NIH HHS UL1 TR001425NCRR NIH HHS UL1 RR025752NIDDK NIH HHS R01 DK076092
6 · The paper itself

Abstract

BACKGROUND &

aimsWhether vitamin D affects lipid profile and cardiovascular disease (CVD) risk is controversial. We evaluated the effect of oral daily vitamin D supplementation on lipid profile and CVD risk in patients with well-controlled type 2 diabetes.

methodsSecondary analysis in the vitamin D for established type 2 diabetes (DDM2) study, a double-blind, randomized, placebo-controlled clinical trial. 127 patients (mean age 60 years) with stable (HbA1c ≤ 7.5%) diabetes managed with lifestyle only or lifestyle plus metformin were randomized to receive 4000 IU/day of vitamin D

resultsThe mean [±SEM] plasma 25-hydroxyvitamin D [25(OH)D] level was higher in the vitamin D vs. the placebo group (20.5 ± 1.18 vs. -1.6 ± 1.2 ng/mL respectively; p < 0.001). There was no statistically significant change in lipid profile, C-reactive protein or CVD risk. Among patients who were not on cholesterol medication (n = 32), vitamin D supplementation reduced TG compared to placebo at week 48 (-18.74 ± 8.91 vs. 9.69 ± 8.60 mg/dL respectively; p = 0.032).

conclusionOne year supplementation with vitamin D REGISTRATION: ClinicalTrials.gov Identifier NCT01736865.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Vitamin DAdultAgedC-Reactive ProteinDietary SupplementsFemaleHumansLipidsMaleMiddle Aged25-hydroxyvitamin DC-Reactive ProteinLipidsVitamin DCardiovascular riskClinical trialDiabetes mellitusLipid profileVitamin D

Identifiers

PMID30352748
PMCPMC6456440
OpenAlexW2896743022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.