ArticleBMC geriatrics2018
Trajectories of allostatic load among older Americans and Britons: longitudinal cohort studies.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Lead exposure, glucocorticoids, and physiological stress across the life course: A systematic review.Environmental pollution (Barking, Essex : 1987) · 2024Pooled it
- Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis.Psychoneuroendocrinology · 2023Pooled it
- Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research.International journal of environmental research and public health · 2022Pooled it
- Life course shaping of allostatic load across 17 countries: Evidence from England, the U.S., Europe, China and Indonesia.medRxiv : the preprint server for health sciences · 2026Article
- Integration of lung function in allostatic load scoring and its impact on mortality prediction.Scientific reports · 2026Article
- Parental socioeconomic position, childhood poverty and healthy aging: retrospective and prospective study of six cohorts across 32 wealthy and developing nations.Frontiers in public health · 2026Article
- Allostatic Load, Social Participation, and Healthy Ageing: Longitudinal Evidence on the Impact of Chronic Stress.Geriatrics (Basel, Switzerland) · 2025Article
- Disparities in Allostatic Load Among Different Races: A Comprehensive Scoping Review.Journal of racial and ethnic health disparities · 2025Review
- Parental socioeconomic position, childhood poverty and healthy ageing: retrospective and prospective study of six cohort surveys across 32 wealthy and developing nations.medRxiv : the preprint server for health sciences · 2025Article
- Early life adversity and late life dementia in the Harmonised Cognitive Assessment Protocol network (U.S., China, England and Europe).medRxiv : the preprint server for health sciences · 2025Article
- Allostatic load score and lifestyle factors in the SWAN cohort: A longitudinal analysis.Public health in practice (Oxford, England) · 2025Article
- Growing up in poverty, growing old in frailty: the life course shaping of health in the United States, England and Europe-a prospective and retrospective study.Scientific reports · 2025Article
- Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers.BMC research notes · 2025Article
- Allostatic load and its determinants in a German sample-Results from the Carla cohort.PloS one · 2025Article
- Allostatic load, a measure of cumulative physiological stress, impairs brain structure but notFrontiers in aging neuroscience · 2025Article
- Association of allostatic load with functional disability in the China Health and Retirement Longitudinal Study.The journal of nutrition, health & aging · 2024Article
- Allostatic Load, Morbidity, and Mortality Among Older Adults: A Multi-Wave Analysis From the National Health and Aging Trends Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Article
- The gender and age perspectives of allostatic load.Frontiers in medicine · 2024Review
- Article
- Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans.Immunity & ageing : I & A · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundDifference in life expectancy between males and females has been suggested to rest on sex difference in physiological dysregulation. But allostatic load, a physiological index, has not been carefully examined for an extended period beyond middle age. We aim to draw longitudinal trajectories of allostatic load in a national sample of older Americans and Britons; also to examine sex-based trajectories and factors behind their differences.
methodsWe studied men and women aged ≥50 years participating in the Health and Retirement Study Waves 8-11, 2006-2012 (N = 15,583 person-years) and the English Longitudinal Study of Ageing Waves 2, 4 and 6, 2004-2012 (N = 14,765 person-years). Because of the difference in provenance, we included different number of biomarkers to calculate allostatic load in HRS and ELSA. In HRS we used 8 biomarkers (systolic and diastolic blood pressure, haemoglobin A1c, high-density lipoprotein, total cholesterol, waist circumference, cystatin C, and C-reactive protein), while ELSA allostatic load was constructed from 10 biomarkers (systolic and diastolic blood pressure, haemoglobin A1c, high-density lipoprotein, total cholesterol, waist circumference, BMI, triglyceride, fibrinogen and C-reactive protein). A growth curve model was fitted to repeated observations of allostatic load, demographic characteristics, socioeconomic position, comorbidities and health behaviours (smoking, drinking, and physical exercise). To account for attrition, a joint model was applied.
resultsThe analysis showed that allostatic load increases linearly with age in the U.S. However, there are different levels for males and females. In England allostatic load follows such different paths that their trajectories cross in later life.
conclusionsSex-based trajectories of allostatic load showed distinct female advantage and are mostly consistent with female advantage in life expectancy.
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