Evidence map›Paper›PMID 30352523›Full record

SynthesisIntegrative cancer therapies2018

Effects of Aerobic and Resistance Exercises on Physical Symptoms in Cancer Patients: A Meta-analysis.

Jiro Nakano, Kaori Hashizume, Takuya Fukushima, Kazumi Ueno, Emi Matsuura, Yuta Ikio, Shun Ishii, Satoru Morishita, Koji Tanaka, Yoko Kusuba

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Integrative cancer therapies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 12 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05401045 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of a Self-designed Metabolic Equivalent Exercise Intervention on Cancer-related Fatigue in Patients With Gastric Cancer

TypeinterventionalSponsorRuijin HospitalRan2023 to 2023Enrolled119ConditionsNeoplasm of StomachArmsMet exercises
NCT07390071 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy

TypeinterventionalSponsorUniversity of UtahRan2025 to 2029Enrolled40ConditionsLymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity SyndromeArmsHome Automated Telemanagement (HAT) Patient Unit
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 12 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  3. Baduanjin exercise for negative emotion of patients undergoing chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Effects of exercise on life satisfaction of people diagnosed with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  5. Effects of internet-based digital health interventions on the physical activity and quality of life of colorectal cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  6. Pooled it
  7. Barriers and facilitators to physical activity in cancer survivors with pain: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  8. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  13. Trial
  14. Examining the effectiveness of combination therapy in alleviating peripheral neuropathy and sleep disorders in breast cancer patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  15. Trial
  16. The potential impact of exercise upon symptom burden in adolescents and young adults undergoing cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  17. Pairing automated exercise coaching with patient-reported symptom monitoring: A way to nudge exercise uptake during cancer treatment?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  18. Trial
  19. Trial
  20. Trial

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jiro Nakano1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kaori Hashizume1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Takuya Fukushima1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kazumi Ueno1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Emi Matsuura1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yuta Ikio1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shun Ishii2 Nagasaki University Hospital, Nagasaki, Japan.
Satoru Morishita2 Nagasaki University Hospital, Nagasaki, Japan.
Koji Tanaka1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yoko Kusuba1 Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nagasaki University · JPNagasaki University Hospital · JPJapanese Red Cross Society, Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to conduct a meta-analysis to establish the effect of exercise interventions on physical symptoms, including fatigue, nausea/vomiting, pain, dyspnea, insomnia, loss of appetite, constipation, and diarrhea in cancer patients and survivors.

methodsWe searched articles published before April 2017 using the following databases: Cochrane Library, PubMed/MEDLINE, CINAHL, Scopus, PEDro, Health & Medical Collection, and Psychology Database. Randomized controlled trials (RCTs) of exercise intervention in cancer patients, which evaluated cancer-related physical symptoms using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30, were included. Symptom scale data were extracted for meta-analysis. Subgroup analyses were performed for exercise types (aerobic, resistance, and mixed exercise programs).

resultsOf the 659 articles, 10 RCTs were included in the meta-analysis, of which the mean PEDro score was 5.43 (SD = 1.28). Fatigue, pain, dyspnea, and insomnia were significantly lower in the intervention group than in the control group at postintervention in cancer patients. However, exercise intervention did not promote or suppress nausea/vomiting, loss of appetite, constipation, and diarrhea in cancer patients. The effect of exercise type on each symptom was not different.

conclusionExercise intervention was confirmed to improve fatigue, pain, and insomnia and might have reduced dyspnea in cancer patients. However, the benefits of exercise on nausea/vomiting, loss of appetite, constipation, and diarrhea were not shown in any exercise type. Further research is warranted to examine the effects of exercise interventions on physical symptoms in cancer patients.

Indexed as

ExerciseExercise TherapyFatigueHumansNauseaNeoplasmsPainQuality of LifeRandomized Controlled Trials as TopicResistance TrainingSleep Initiation and Maintenance DisordersSurvivorscancerdyspneaexercisemeta-analysisphysical symptoms

Identifiers

PMID30352523
PMCPMC6247562
OpenAlexW2898141175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.