Evidence map›Paper›PMID 30352424›Full record

ReviewEndocrine connections2018

Circulating vitamin D level and mortality in prostate cancer patients: a dose-response meta-analysis.

Zhen-Yu Song, Qiuming Yao, Zhiyuan Zhuo, Zhe Ma, Gang Chen

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine connections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07598032 (Comparative Analysis of Immunological Responses to Vitamin D Replacement Therapy in Black and West African Men Diagnosed With Prostate Cancer), which is not on this map. Cited by 43 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07598032 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparative Analysis of Immunological Responses to Vitamin D Replacement Therapy in Black and West African Men Diagnosed With Prostate Cancer: Elucidating Differential Effects on Immune Function Between Patients With Localized Disease and Those With Metastatic Progression

TypeinterventionalSponsorUniversity of Ilorin Teaching HospitalRan2026 to 2028Enrolled200ConditionsProstate Cancer (Adenocarcinoma), Vitamin D on Tumor Response and Inflammatory MarkersArmsvitamin D 25(OH)D
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials.Annals of oncology : official journal of the European Society for Medical Oncology · 2019
    Pooled it
  8. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2019
    Pooled it
  9. Trial
  10. Article
  11. Article
  12. Article
  13. The double disparity: Vitamin D deficiency and lethal prostate cancer in black men.The Journal of steroid biochemistry and molecular biology · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhen-Yu SongDepartment of Urology, Jinshan Hospital of Fudan University, Shanghai, China.
Qiuming YaoDepartment of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
Zhiyuan ZhuoDepartment of Urology, Jinshan Hospital of Fudan University, Shanghai, China.
Zhe MaDepartment of Urology, Jinshan Hospital of Fudan University, Shanghai, China.
Gang ChenDepartment of Urology, Jinshan Hospital of Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies investigating the association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer yielded controversial results. We conducted a dose-response meta-analysis to elucidate the relationship. PubMed and EMBASE were searched for eligible studies up to July 15, 2018. We performed a dose-response meta-analysis using random-effect model to calculate the summary hazard ratio (HR) and 95% CI of mortality in patients with prostate cancer. Seven eligible cohort studies with 7808 participants were included. The results indicated that higher vitamin D level could reduce the risk of death among prostate cancer patients. The summary HR of prostate cancer-specific mortality correlated with an increment of every 20 nmol/L in circulating vitamin D level was 0.91, with 95% CI 0.87-0.97, P = 0.002. The HR for all-cause mortality with the increase of 20 nmol/L vitamin D was 0.91 (95% CI: 0.84-0.98, P = 0.01). Sensitivity analysis suggested the pooled HRs were stable and not obviously changed by any single study. No evidence of publications bias was observed. This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.

Indexed as

meta-analysismortalityprostate cancervitamin D

Identifiers

PMID30352424
PMCPMC6240137

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.