Evidence map›Paper›PMID 30352270›Full record

ArticleMagnetic resonance imaging2019

Preliminary evaluation of accelerated microscopic diffusional kurtosis imaging (μDKI) in a rodent model of epilepsy.

Yang Ji, Dongshuang Lu, Limin Wu, Bensheng Qiu, Yi-Qiao Song, Phillip Zhe Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yang JiCenter for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, China; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.
Dongshuang LuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.
Limin WuNeuroscience Center, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.
Bensheng QiuCenter for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, China.
Yi-Qiao SongAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America; Schlumberger-Doll Research Center, Cambridge, MA, United States of America.
Phillip Zhe SunAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America; Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States of America; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States of America. Electronic address: pzhesun@emory.edu.
Harvard University · USUniversity of Science and Technology of China · CN

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Establishment of fast pH MRI for imaging metabolic injury during acute strokeR01NS083654 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Phillip Zhe Sun · 2013 to 2026
$4.0M
Development of kurtosis MRI to image acute stroke patientsR21NS085574 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SUN, PHILLIP ZHE · 2013 to 2014
$475k
NIH HHS P51 OD011132NINDS NIH HHS R01 NS083654NINDS NIH HHS R21 NS085574
6 · The paper itself

Abstract

purposeOur study aimed to develop accelerated microscopic diffusional kurtosis imaging (μDKI) and preliminarily evaluated it in a rodent model of chronic epilepsy.

methodsWe investigated two μDKI acceleration schemes of reduced sampling density and angular range in a phantom and wild-type rats, and further tested μDKI method in pilocarpine-induced epilepsy rats using a 4.7 Tesla MRI. Single slice average μD

resultsThe kurtosis maps from two accelerated μDKI sampling schemes (sampling density and range) are very similar to that using fully sampled data (SSIM > 0.95). For the epileptic models, μDKI showed noticeably different contrast from those obtained with conventional DKI. Specifically, the average μK

conclusionsOur study demonstrated the feasibility of accelerated in vivo μDKI. Our work revealed that μDKI provides complementary information to conventional DKI method, suggesting that advanced DKI sequences are promising to elucidate tissue microstructure in neurological diseases.

Indexed as

AnimalsDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingDisease Models, AnimalEpilepsyHumansMalePhantoms, ImagingRatsRats, Sprague-Dawley

Identifiers

PMID30352270
PMCPMC6583913
OpenAlexW2896817722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.