Evidence map›Paper›PMID 30352226›Full record

Trial reportOphthalmology2019

A Randomized Trial of Binocular Dig Rush Game Treatment for Amblyopia in Children Aged 7 to 12 Years.

Pediatric Eye Disease Investigator Group, Jonathan M Holmes, Ruth E Manny, Elizabeth L Lazar, Eileen E Birch, Krista R Kelly, Allison I Summers, Stacy R Martinson, Aparna Raghuram, Jeffrey D Colburn and 5 more

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 9 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02983552 nacompletednot on this map

Binocular Dig Rush Game Treatment for Amblyopia

TypeinterventionalSponsorJaeb Center for Health ResearchRan2017 to 2020Enrolled320ConditionsAmblyopiaArmsiPad®, Spectacle correction
NCT06150391 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Randomized Controlled Trial of a Dichoptic Gabor Videogame Program to Improve Visual Function in Children With Amblyopia

TypeinterventionalSponsorHospital de MeridaRan2023 to 2024Enrolled120ConditionsAmblyopiaArmsVisionary: computer exercises using dichoptic Gabor Patches and band-filtered noise masks, Patching
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 9 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Occlusion for stimulus deprivation amblyopia.The Cochrane database of systematic reviews · 2020
    Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Barriers to successful dichoptic treatment for amblyopia in young children.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Trial
  14. Trial
  15. Trial
  16. A randomized clinical trial of contrast increment protocols for binocular amblyopia treatment.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020
    Trial
  17. Review
  18. Article
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 2 countries.

Pediatric Eye Disease Investigator Group
Jonathan M HolmesDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota. Electronic address: pedig@jaeb.org.
Ruth E MannyUniversity of Houston College of Optometry, Houston, Texas.
Elizabeth L LazarJaeb Center for Health Research, Tampa, Florida.
Eileen E BirchRetina Foundation of the Southwest, Dallas, Texas.
Krista R KellyRetina Foundation of the Southwest, Dallas, Texas.
Allison I SummersCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Stacy R MartinsonVirginia Pediatric Eye Center, Virginia Beach, Virginia.
Aparna RaghuramBoston Children's Hospital, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Jeffrey D ColburnSpokane Eye Clinic, Spokane, Washington.
Christine LawDepartment of Ophthalmology, Queen's University, Kingston, Ontario, Canada.
Justin D MarshChildren's Mercy Hospitals and Clinics, Kansas City, Missouri.
Derek P BitnerWolfe Eye Clinic, West Des Moines, Iowa.
Raymond T KrakerJaeb Center for Health Research, Tampa, Florida.
David K WallaceDepartment of Ophthalmology, Indiana University, Indianapolis, Indiana.
Jaeb Center for Health Research · USRetina Foundation of the Southwest · USBoston Children's Hospital · USChildren's Mercy Hospital · USIndiana University – Purdue University Indianapolis · USMayo Clinic · USOregon Health & Science University · USQueen's University · CARockwood Clinic · USUniversity of Houston · USVirginia Eye Consultants · USWolfe Eye Clinic · US

Funding

Pediatric Eye Disease Investigator Group Coordinating CenterU10EY011751 · NEI · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI KRAKER, RAYMOND · 1997 to 2018
$75.2M
Pediatric Eye Disease Investigator Group NetworkUG1EY011751 · NEI · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI Raymond Kraker, Stacy Pineles · 2019 to 2026
$53.7M
Pediatric Eye Disease Investigator Group: Chair's OfficeU10EY018810 · NEI · MAYO CLINIC ROCHESTER · PI HOLMES, JONATHAN M · 2009 to 2013
$3.5M
PEDIATRIC EYE DISEASE INVESTIGATOR GROUP: CHAIR'S OFFICEU10EY023198 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI WALLACE, DAVID K · 2014 to 2018
$1.4M
NEI NIH HHS U10 EY011751NEI NIH HHS U10 EY018810NEI NIH HHS U10 EY023198NEI NIH HHS UG1 EY011751
6 · The paper itself

Abstract

purposeTo compare visual acuity (VA) improvement in children aged 7 to 12 years with amblyopia treated with a binocular iPad game plus continued spectacle correction vs. continued spectacle correction alone.

designMulticenter randomized clinical trial.

participantsOne hundred thirty-eight participants aged 7 to 12 years with amblyopia (33-72 letters, i.e., approximately 20/200 to 20/40) resulting from strabismus, anisometropia, or both. Participants were required to have at least 16 weeks of optical treatment in spectacles if needed or demonstrate no improvement in amblyopic-eye visual acuity (VA) for at least 8 weeks prior to enrollment.

methodsEligible participants (mean age 9.6 years, mean baseline VA of 59.6 letters, history of prior amblyopia treatment other than spectacles in 96%) were randomly assigned to treatment for 8 weeks with the dichoptic binocular Dig Rush iPad game (prescribed for 1 hour per day 5 days per week) plus spectacle wear if needed (n = 69) or continued spectacle correction alone if needed (n = 69).

main outcome measuresChange in amblyopic-eye VA from baseline to 4 weeks, assessed by a masked examiner.

resultsAt 4 weeks, mean amblyopic-eye VA letter score improved from baseline by 1.3 (2-sided 95% confidence interval [CI]: 0.1-2.6; 0.026 logMAR) with binocular treatment and by 1.7 (2-sided 95% CI: 0.4-3.0; 0.034 logMAR) with continued spectacle correction alone. After adjusment for baseline VA, the letter score difference between groups (binocular minus control) was -0.3 (95% CI: -2.2 to 1.5, P = 0.71, difference of -0.006 logMAR). No difference in letter scores was observed between groups when the analysis was repeated after 8 weeks of treatment (adjusted mean: -0.1, 98.3% CI: -2.4 to 2.1). For the binocular group, adherence data from the iPad indicated that slightly more than half of the participants (58% and 56%) completed >75% of prescribed treatment by the 4- and 8-week visits, respectively.

conclusionsIn children aged 7 to 12 years who have received previous treatment for amblyopia other than spectacles, there was no benefit to VA or stereoacuity from 4 or 8 weeks of treatment with the dichoptic binocular Dig Rush iPad game.

Indexed as

Video GamesAmblyopiaAnisometropiaChildComputers, HandheldEyeglassesFemaleFollow-Up StudiesHumansMaleStrabismusTreatment OutcomeVision, BinocularVisual Acuity

Identifiers

PMID30352226
PMCPMC6402824
OpenAlexW2897470875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.