Evidence map›Paper›PMID 30352172›Full record

ArticleDevelopmental cell2018

Hijacking a Morphogenesis Proteinase for Cancer Cell Invasion.

Nasreen Akhtar

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Ubiquitin ligases: guardians of mammalian development.Nature reviews. Molecular cell biology · 2022
    Review
  2. Identification of Key Genes Associated with Brain Metastasis from Breast Cancer: A Bioinformatics Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Nasreen AkhtarDepartment of Oncology and Metabolism, The Bateson Centre, University of Sheffield, Beech Hill Road, Sheffield, UK. Electronic address: n.akhtar@sheffield.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A long-standing question in biology is whether cancer cells exploit developmental processes to invade the surrounding stroma. In this issue of Developmental Cell, Feinberg et al. (2018) identify the matrix metalloproteinase Mmp14 as a key driver of mammary invasion common to both development and cancer but expose an underlying twist.

Indexed as

Matrix Metalloproteinase 14MorphogenesisBreastEpithelial CellsHumansNeoplasm InvasivenessProteolysisMatrix Metalloproteinase 14

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.