Evidence map›Paper›PMID 30352124›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis.

Huichuan Qi, Jong Kil Kim, Pin Ha, Xiaoyan Chen, Eric Chen, Yao Chen, Jiayi Li, Hsin Chuan Pan, Mengliu Yu, Yasamin Mohazeb and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026
    Review
  4. Article
  5. Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).International journal of molecular medicine · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Huichuan QiDepartment of Orthodontics, School and Hospital of Stomatology, Jilin University, Changchun, Jilin, PR China.
Jong Kil KimDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Pin HaDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Xiaoyan ChenDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Eric ChenDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Yao ChenDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Jiayi LiDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Hsin Chuan PanDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Mengliu YuDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Yasamin MohazebDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Sophia AzerDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Lloyd BaikDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Jin Hee KwakDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Kang TingDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Xinli ZhangDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Min HuDepartment of Orthodontics, School and Hospital of Stomatology, Jilin University, Changchun, Jilin, PR China.
Chia SooDivision of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USJilin University · CNOrthopaedic Hospital · USStomatology Hospital · CNZhejiang University · CN

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2M
NELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0M
Wnt and PPARy Signaling in Nell-1 and BMP2 Mediated Bone RegenerationR01AR061399 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA · 2012 to 2016
$1.7M
Novel systemic PEGylated NELL-1 therapy for craniofacial osteoporosisK08DE026805 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KWAK, JIN HEE · 2017 to 2020
$633k
NCATS NIH HHS UL1 TR000124NIAMS NIH HHS R01 AR061399NIAMS NIH HHS R01 AR066782NIAMS NIH HHS R01 AR068835NIDCR NIH HHS K08 DE026805
6 · The paper itself

Abstract

NELL-1, an osteoinductive protein, has been shown to regulate skeletal ossification. Interestingly, an interstitial 11p14.1-p15.3 deletion involving the Nell-1 gene was recently reported in a patient with short stature and delayed fontanelle closure. Here we sought to define the role of Nell-1 in endochondral ossification by investigating Nell-1-specific inactivation in Col2α1-expressing cell lineages. Nell-1

Indexed as

OsteogenesisAnimalsCalcium-Binding ProteinsChondrocytesDwarfismHedgehog ProteinsMiceMice, KnockoutOsteoporosisParathyroid Hormone-Related ProteinX-Ray MicrotomographyCalcium-Binding ProteinsHedgehog Proteinsihh protein, mouseNell1 protein, mouseParathyroid Hormone-Related ProteinCONDITIONAL KNOCKOUT MOUSE MODELENDOCHONDRAL OSSIFICATIONEPIPHYSEAL HOMEOSTASISIHH-PTHRP SIGNALING LOOPNELL-1

Identifiers

PMID30352124
PMCPMC6677149
OpenAlexW2898332707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.