Trial reportPloS one2018
A lifestyle intervention improves sexual function of women with obesity and infertility: A 5 year follow-up of a RCT.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Preconception lifestyle advice for people with infertility.The Cochrane database of systematic reviews · 2021Pooled it
- Effects of tocolysis with nifedipine or atosiban on child outcome: follow-up of the APOSTEL III trial.BJOG : an international journal of obstetrics and gynaecology · 2020Trial
- Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective.Medicina (Kaunas, Lithuania) · 2026Review
- Sexual behavior of young women with obesity indicated for bariatric treatment: A cross-sectional study.The Journal of international medical research · 2025Article
- Association between relative fat mass and female infertility among reproductive-aged women from NHANES 2013-2020.Scientific reports · 2025Article
- Association between BMI and increased time-to-pregnancy in planned pregnancy couples: a cohort study in Guangzhou, China.BMC public health · 2024Article
- Association between cardiometabolic index and female infertility: A population-based study.PloS one · 2024Article
- Sexual Disability in Low Back Pain: Diagnostic and Therapeutic Framework for Physical Therapists.Healthcare (Basel, Switzerland) · 2023Article
- Sexual function and sexual satisfaction in individuals undergoing infertility: A systematic review.International journal of reproductive biomedicine · 2023Review
- Higher waist circumference is associated with increased likelihood of female infertility: NHANES 2017-2020 results.Frontiers in endocrinology · 2023Article
- Erectile and sexual dysfunction in male and female patients with celiac disease: A cross-sectional observational study.Andrology · 2022Observational
- Lifestyle Interventions for Adults with Infertility.Journal of lifestyle medicine · 2022Review
- Effects of lifestyle on sexual function among postmenopausal women.African health sciences · 2021Article
- Distinct Protocols of Physical Exercise May Improve Different Aspects of Well-being in Women With Polycystic Ovary Syndrome.American journal of lifestyle medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and infertility are associated with poorer sexual function. We have previously shown that a lifestyle intervention in women with obesity and infertility reduced weight and improved cardiometabolic health and quality of life, which may positively affect sexual function. We now report on sexual function 5 years after randomization. METHODS AND
findingsIn total 577 women, between 18-39 years of age, with infertility and a BMI ≥29 kg/m2 were randomized to a six-month lifestyle intervention targeting physical activity, diet and behavior modification or prompt infertility care as usual. Intercourse frequency and sexual function were assessed with the McCoy Female Sexuality Questionnaire (MFSQ), 5.4±0.8 years after randomization. 550 women could be approached for the follow-up study, of whom 84 women in the intervention and 93 in the control group completed the MFSQ. Results were adjusted for duration of infertility, polycystic ovary syndrome and whether women were attempting to conceive. The intervention group more often reported having had intercourse in the past 4 weeks compared to the control group (aOR: 2.3 95% CI 0.96 to 5.72). Among women reporting intercourse in the past 4 weeks, the intervention group (n = 75) had intercourse more frequently (6.6±5.8 vs. 4.9±4.0 times; 95% CI 0.10 to 3.40) and had higher scores for vaginal lubrication (16.5±3.0 vs. 15.4±3.5; 95% CI 0.15 to 2.32) and total 'sexual function' score (96.5±14.2 vs. 91.4±12.8; 95% CI 0.84 to 9.35) compared to the control group (n = 72). Sexual interest, satisfaction, orgasm and sex partner scores did not differ statistically between the groups. The intervention effect on sexual function was for 21% mediated by the change in moderate to vigorous physical activity.
conclusionA six-month lifestyle intervention in women with obesity and infertility led to more frequent intercourse, better vaginal lubrication and overall sexual function 5 years after the intervention. (Trial Registration: NTR1530).
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