Evidence map›Paper›PMID 30352015›Full record

ArticleJournal of biopharmaceutical statistics2019

Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs.

Reid D Landes, Shelly Y Lensing, Martin Hauer-Jensen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biopharmaceutical statistics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reid D Landesa Department of Biostatistics , University of Arkansas for Medical Sciences , Little Rock , Arkansas , USA.
Shelly Y Lensinga Department of Biostatistics , University of Arkansas for Medical Sciences , Little Rock , Arkansas , USA.
Martin Hauer-Jensenb Division of Radiation Health , University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System , Little Rock , Arkansas , USA.ORCID 0000-0003-1776-4325

Funding

Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI WOLFE, TATIANA · 2015 to 2024
$21.1M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Algorithms to generate designs of potency experiments that use far fewer animalsR21CA184756 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI LANDES, REID D. · 2015 to 2016
$356k
NCATS NIH HHS UL1 TR000039NCI NIH HHS R21 CA184756NIAID NIH HHS U19 AI067798NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

The relative potency of one agent to another is commonly represented by the ratio of two quantal response parameters; for example, the LD

Indexed as

AnimalsBayes TheoremComputer SimulationDose-Response Relationship, DrugHumansLethal Dose 50Odds RatioProbabilityRadiation-Protective AgentsResearch DesignToxicologyRadiation-Protective Agents3Rsdose reduction factorparallel-line assayPowersample size

Identifiers

PMID30352015
PMCPMC6450382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.