Evidence map›Paper›PMID 30351478›Full record

ArticleJournal of medical virology2019

Identification of hepatitis B virus genotype I in Thailand.

Vera Holzmayer, Robert Hance, Patricia Defechereux, Robert Grant, Mary C Kuhns, Gavin Cloherty, Mary A Rodgers

Abstract read
In one paragraph

Article in Journal of medical virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vera HolzmayerAbbott Laboratories, Infectious Disease Research, Abbott Park, Illinois.
Robert HanceUniversity of California San Francisco, San Francisco, California.
Patricia DefechereuxUniversity of California San Francisco, San Francisco, California.
Robert GrantUniversity of California San Francisco, San Francisco, California.
Mary C KuhnsAbbott Laboratories, Infectious Disease Research, Abbott Park, Illinois.
Gavin ClohertyAbbott Laboratories, Infectious Disease Research, Abbott Park, Illinois.
Mary A RodgersAbbott Laboratories, Infectious Disease Research, Abbott Park, Illinois.ORCID 0000-0001-8815-8651

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Chemoprophylaxis for HIV Prevention in Men SupplementU01AI064002 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GRANT, ROBERT M. · 2005 to 2011
$41.3M
BIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9M
Chemoprophylaxis and HIV-Host InteractionsR01AI062333 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GRANT, ROBERT M. · 2004 to 2011
$6.2M
Chemoprophylaxis and HIV Host InteractionsR01AI118575 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANT, ROBERT M. · 2015 to 2019
$2.9M
NCRR NIH HHS UL1 RR024131NIAID NIH HHS R01 AI062333NIAID NIH HHS R01 AI118575NIAID NIH HHS T32 AI007641NIAID NIH HHS U01 AI064002
6 · The paper itself

Abstract

The rare hepatitis B virus genotype I (HBV-I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV-I specimen from Thailand, with detectable HBsAg despite a 10-amino-acid truncation. This HBV-I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV-I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV-I classification as a unique genotype.

Indexed as

GenotypeChinaDNA, ViralHepatitis BHepatitis B Surface AntigensHepatitis B virusHumansSequence Analysis, DNASequence DeletionThailandDNA, ViralHepatitis B Surface Antigenshepatitis B virusrecombinant virusrecombinationvirus classification

Identifiers

PMID30351478
PMCPMC6618046

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.