ArticleLab on a chip2018
Selective assembly and functionalization of miniaturized redox capacitor inside microdevices for microbial toxin and mammalian cell cytotoxicity analyses.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Smart microdevices for biomedical drug delivery: endogenous stimuli as the key to safer therapeutics.RSC advances · 2026Review
- Redox-enabled electronic interrogation and feedback control of hierarchical and networked biological systems.Nature communications · 2023Article
- Recent advances in electrochemical strategies for bacteria detection.BioImpacts : BI · 2022Review
- Multiplexed assessment of engineered bacterial constructs for intracellular β-galactosidase expression by redox amplification on catechol-chitosan modified nanoporous gold.Mikrochimica acta · 2021Article
- Bioelectronic control of a microbial community using surface-assembled electrogenetic cells to route signals.Nature nanotechnology · 2021Article
- A redox-based electrogenetic CRISPR system to connect with and control biological information networks.Nature communications · 2020Article
- 3D-Printed electrochemical sensor-integrated transwell systems.Microsystems & nanoengineering · 2020Article
- Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes.Microsystems & nanoengineering · 2020Article
- Catechol-Based Capacitor for Redox-Linked Bioelectronics.ACS applied electronic materials · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We report a novel strategy for bridging information transfer between electronics and biological systems within microdevices. This strategy relies on our "electrobiofabrication" toolbox that uses electrode-induced signals to assemble biopolymer films at spatially defined sites and then electrochemically "activates" the films for signal processing capabilities. Compared to conventional electrode surface modification approaches, our signal-guided assembly and activation strategy provides on-demand electrode functionalization, and greatly simplifies microfluidic sensor design and fabrication. Specifically, a chitosan film is selectively localized in a microdevice and is covalently modified with phenolic species. The redox active properties of the phenolic species enable the film to transduce molecular to electronic signals (i.e., "molectronic"). The resulting "molectronic" sensors are shown to facilitate the electrochemical analysis in real time of biomolecules, including small molecules and enzymes, to cell-based measurements such as cytotoxicity. We believe this strategy provides an alternative, simple, and promising avenue for connecting electronics to biological systems within microfluidic platforms, and eventually will enrich our abilities to study biology in a variety of contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.