Evidence map›Paper›PMID 30351168›Full record

ReviewAIDS research and human retroviruses2019

Current Strategies for Elimination of HIV-1 Latent Reservoirs Using Chemical Compounds Targeting Host and Viral Factors.

Maxime J Jean, Guillaume Fiches, Tsuyoshi Hayashi, Jian Zhu

Open access · bronzeAbstract readReview
In one paragraph

Review in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Screening for gene expression fluctuations reveals latency-promoting agents of HIV.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. HSF1 Activation Can Restrict HIV Replication.ACS infectious diseases · 2020
    Article
  17. Article
  18. Review
  19. Article
  20. Targeting HIV-1 proviral transcription.Current opinion in virology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Maxime J Jean1 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
Guillaume Fiches2 Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Tsuyoshi Hayashi3 National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan .
Jian Zhu2 Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
The Ohio State University Wexner Medical Center · USNational Institute of Biomedical Innovation, Health and Nutrition · JPUniversity of Rochester Medical Center · US

Funding

University of Rochester Mentoring Environment: Nurturing Training Opportunities in Research (UR-MENTOR)T32GM007356 · NIGMS · UNIVERSITY OF ROCHESTER · PI O'BANION, M. KERRY · 1985 to 2023
$15.1M
Virology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6M
The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
Training in Cellular, Biochemical and Molecular SciencesT32GM068411 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2005 to 2019
$3.9M
Investigation of Latency Promoting Genes (LPGs) in HIV Oral Reservoir CellsR01DE025447 · NIDCR · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2015 to 2019
$1.9M
Role of FACT Proteins in Regulating HIV Transcription and LatencyR01GM117838 · NIGMS · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2015 to 2018
$1.2M
Cooperation of BRD4 and TAT Associated Proteins in HIV Transcription and LatencyR33AI116180 · NIAID · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2016 to 2018
$1.2M
Cooperation of BRD4 and TAT Associated Proteins in HIV Transcription and LatencyR21AI116180 · NIAID · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2014 to 2015
$421k
NIAID NIH HHS P30 AI078498NIAID NIH HHS R21 AI116180NIAID NIH HHS R33 AI116180NIAID NIH HHS T32 AI007285NIDCR NIH HHS R01 DE025447NIGMS NIH HHS R01 GM117838NIGMS NIH HHS T32 GM007356NIGMS NIH HHS T32 GM068411
6 · The paper itself

Abstract

Since the implementation of combination antiretroviral therapy (cART), rates of HIV type 1 (HIV-1) mortality, morbidity, and newly acquired infections have decreased dramatically. In fact, HIV-1-infected individuals under effective suppressive cART approach normal life span and quality of life. However, long-term therapy is required because the virus establish a reversible state of latency in memory CD4

Indexed as

Antiviral AgentsBiomedical ResearchCD4-Positive T-LymphocytesDrug DiscoveryHIV-1HIV InfectionsHost-Pathogen InteractionsHumansVirus LatencyAntiviral Agents“block and lock”HIV cureHIV latencylatency-promoting agentslatency-reversing agents“shock and kill”

Identifiers

PMID30351168
PMCPMC6343200
OpenAlexW2897674559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.