ArticlePediatric blood & cancer2019
Racial and ethnic differences in survival of pediatric patients with brain and central nervous system cancer in the United States.
Article in Pediatric blood & cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Social determinants of health and pediatric cancer survival: A systematic review.Pediatric blood & cancer · 2022Pooled it
- Racial and ethnic disparities among children with primary central nervous system tumors in the US.Journal of neuro-oncology · 2021Pooled it
- The Mediating Effect of Socioeconomic Status and Persistent Poverty on Racial and Ethnic Disparities in Pediatric Cancer Mortality in the United States.Cancer medicine · 2026Article
- Global, regional, and national burden of brain and central nervous system cancer in children and adolescents, 1990-2021: A systematic analysis of the Global Burden of Disease study 2021.Pediatric investigation · 2025Article
- Article
- Racial/ethnic disparities in all-cause and cause-specific death among children with malignant central nervous system tumours: a registry-based cohort retrospective analysis.EClinicalMedicine · 2024Article
- The Association Between Socioeconomic Factors at Diagnosis and Survival in Medulloblastoma: A Propensity Score-Matched Analysis and Population-Based Study.Journal of racial and ethnic health disparities · 2024Article
- Medical Record Level-Evaluation of Impact of Demographic and Socioeconomic Factors on Pediatric Neuro-Oncology Outcomes at Children's Hospital Colorado.Research square · 2024Article
- Incidence and 5-year survival of children and adolescents with hepatoblastoma in the United States.Pediatric blood & cancer · 2022Article
- Ethnic and socioeconomic disparities in survival of children and adolescents with CNS tumors in Southern Israel.Neuro-oncology practice · 2022Article
- Race, Zoonoses and Animal Assisted Interventions in Pediatric Cancer.International journal of environmental research and public health · 2022Review
- Population-based analysis of CNS tumor diagnoses, treatment, and survival in congenital and infant age groups.Journal of neuro-oncology · 2022Article
- Racial/ethnic, socioeconomic, and geographic survival disparities in adolescents and young adults with primary central nervous system tumors.Pediatric blood & cancer · 2021Article
- Epidemiology and prognostic factors of pediatric brain tumor survival in the US: Evidence from four decades of population data.Cancer epidemiology · 2021Article
- Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis.Scientific reports · 2021Article
- Article
- Automated pediatric brain tumor imaging assessment tool from CBTN: Enhancing suprasellar region inclusion and managing limited data with deep learning.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundBrain and central nervous system (CNS) cancer is the leading cause of cancer death among children and adolescents in the United States. Data from earlier studies suggested racial and ethnic differences in survival among pediatric patients with brain tumor. This study examined racial/ethnic difference in survival using national data and considered the effects of demographic and clinical factors.
methodsUsing National Program of Cancer Registries data, 1-, 3-, and 5-year relative survival (cancer survival in the absence of other causes of death) was calculated for patients with brain and CNS cancer aged < 20 years diagnosed during 2001-2008 and followed up through 2013. Racial and ethnic differences in survival were measured by sex, age, economic status, stage, anatomic location, and histology. Adjusted racial and ethnic difference in 5-year cancer specific survival was estimated using multivariable Cox regression analysis.
resultsUsing data from 11 302 patients, 5-year relative survival was 77.6% for non-Hispanic white patients, 69.8% for non-Hispanic black patients, and 72.9% for Hispanic patients. Differences in relative survival by race/ethnicity existed within all demographic groups. Based on multivariable analysis, non-Hispanic black patients had a higher risk of death at 5 years after diagnosis compared to non-Hispanic white patients (adjusted hazard ratio = 1.2, 95% confidence interval, 1.1-1.4).
conclusionsPediatric brain and CNS cancer survival differed by race/ethnicity, with non-Hispanic black patients having a higher risk of death than non-Hispanic white patients. Future investigation of access to care, social and economic barriers, and host genetic factors might identify reasons for disparities in survival.
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