ArticleJournal of biomedical optics2018
Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Method for retrospective, respiratory-gated, anatomical optical coherence tomography for airway wall elastography.Journal of biomedical optics · 2025Article
- Article
- Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025Review
- Evaluation of Tracheal Stenosis in Rabbits Using Multispectral Optoacoustic Tomography.Frontiers in bioengineering and biotechnology · 2022Article
- All-fiber probes for endoscopic optical coherence tomography of the large airways.Applied optics · 2021Article
- Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.IEEE transactions on bio-medical engineering · 2021Article
- Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty.Journal of biomedical optics · 2020Article
- Localized compliance measurement of the airway wall using anatomic optical coherence elastography.Optics express · 2019Article
- Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review.Otolaryngology (Sunnyvale, Calif.) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with dynamic and static ventilation protocols. Validation of dynamic aOCT luminal cross-sectional area (CSA) measurements against Cine CT, obtained during the same exam, showed an aggregate difference of 15 % ± 3 % . aOCT-derived CSA obtained in the in vivo trachea also exhibited hysteresis as a function of pressure, depicting the viscoelastic nature of the airway wall. The volumetric imaging capabilities were validated by comparing aOCT- and CT-derived geometries of the porcine airway spanning nine generations from the trachea to the bronchioles. The ability to delineate regional differences in airway viscoelastic properties, by measuring airway deformation using aOCT combined with intraluminal pressure, paves the way to patient-specific models of dynamic airway collapse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.