ArticlePhysiological reports2018
Force-frequency relationship and early relaxation kinetics are preserved upon sarcoplasmic blockade in human myocardium.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Feature-Tracking Method Can Estimate Right Ventricular Contractile Properties in Rats With Pulmonary Hypertension.Circulation reports · 2025Article
- Maturation of human cardiac organoids enables complex disease modeling and drug discovery.Nature cardiovascular research · 2025Article
- Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.NPJ Regenerative medicine · 2025Article
- Altered endoplasmic reticulum calcium loading in human PLN-R14del cardiomyopathy.Frontiers in cell and developmental biology · 2025Article
- An arrhythmogenic metabolite in atrial fibrillation.Journal of translational medicine · 2023Article
- Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue.Stem cell reports · 2022Article
- The Case for, and Challenges of, Human Cardiac Tissue in Advancing Phosphoprotein Research.Frontiers in physiology · 2022Review
- Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics.Archives of biochemistry and biophysics · 2021Article
- Impact of etiology on force and kinetics of left ventricular end-stage failing human myocardium.Journal of molecular and cellular cardiology · 2021Article
- Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology.American journal of physiology. Heart and circulatory physiology · 2021Article
- Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format.Stem cell reports · 2020Article
- Stretching single titin molecules from failing human hearts reveals titin's role in blunting cardiac kinetic reserve.Cardiovascular research · 2020Article
- Modeling heart failure in animal models for novel drug discovery and development.Expert opinion on drug discovery · 2019Review
- Force-frequency relationship and early relaxation kinetics are preserved upon sarcoplasmic blockade in human myocardium.Physiological reports · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
In this study, we investigated the quantitative and qualitative role of the sarcoplasmic reticulum (SR) in the regulation of the force-frequency relationship (FFR). We blocked the function of SR with cyclopiazonic acid (CPA) and ryanodine and measured twitch kinetics and developed force at various stimulation frequencies in nonfailing and failing intact human right ventricular trabeculae. We found that developed forces are only slightly reduced upon SR blockade, while the positive FFR in nonfailing trabeculae and negative FFR in failing trabeculae were both preserved. The contraction kinetics (dF/dt, dF/dt/F, and time to peak), however, were significantly slower at all frequencies tested. Kinetics of first 50% of relaxation (RT50) was not affected by SR blockade. Kinetics of entire relaxation process (RT90) was overall slower at low frequencies, but not at high frequencies. From our findings, we conclude that the SR is not essential for FFR, and its role in regulation of FFR lies mostly in contraction kinetics. Unlike small rodents, human myocardium contractile function is near-normal in absence of a functional SR with little changes in contractile force, and with preservation with the main regulation of FFR.
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