Evidence map›Paper›PMID 30350428›Full record

ReviewGenes, chromosomes & cancer2019

Molecular mechanisms of long noncoding RNAs-mediated cancer metastasis.

Yajuan Li, Sergey D Egranov, Liuqing Yang, Chunru Lin

Open access · greenAbstract readReview
In one paragraph

Review in Genes, chromosomes & cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. The RNA NCell death & disease · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. The RNA NResearch square · 2024
    Article
  9. Long noncoding RNAs in ubiquitination, protein degradation, and human diseases.Biochimica et biophysica acta. Gene regulatory mechanisms · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yajuan LiDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sergey D EgranovDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Liuqing YangDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Chunru LinDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-6473-8229
The University of Texas MD Anderson Cancer Center · US

Funding

Combinatorial Treatment Strategies to Counteract EGFR ResistanceR01CA218036 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YANG, LIUQING · 2017 to 2021
$1.8M
Significance of Inhibiting Long Non-coding RNAs in Advanced Breast CancerR01CA218025 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIN, CHUNRU · 2017 to 2020
$1.5M
Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ERR00DK094981 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIN, CHUNRU · 2013 to 2015
$747k
Mechanistic Roles of Long mcRNA-regulated Gene Transcription in Prostate CancerR00CA166527 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YANG, LIUQING · 2013 to 2015
$684k
NCI NIH HHS 1 R01 CA218025-01NCI NIH HHS 1 R01 CA218036-01NCI NIH HHS CA218025-01R01NCI NIH HHS CA218036-01NCI NIH HHS R00 CA166527NCI NIH HHS R00CA166527R01NCI NIH HHS R01 CA218025NCI NIH HHS R01 CA218036NIDDK NIH HHS R00 DK094981NIDDK NIH HHS R00DK094981NIH HHS R00CA166527NIH HHS R00DK094981
6 · The paper itself

Abstract

Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ-specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.

Indexed as

AnimalsGene Expression Regulation, NeoplasticGenetic TherapyHumansNeoplasm MetastasisNeoplasmsRNA, Long NoncodingRNA, Long Noncodingangiogenesiscancercell invasioncolonizehypoxialong noncoding RNAsmetastasisoligonucleotide therapeuticsorgan-specificsmall molecule inhibitortumor microenvironment

Identifiers

PMID30350428
PMCPMC10642708
OpenAlexW2897227202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.