Evidence map›Paper›PMID 30350402›Full record

ArticlePhysiological reports2018

The renal and blood pressure response to low sodium diet in P2X4 receptor knockout mice.

Eilidh Craigie, Robert I Menzies, Casper K Larsen, Grégory Jacquillet, Monique Carrel, Scott S Wildman, Johannes Loffing, Jens Leipziger, David G Shirley, Matthew A Bailey and 1 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Claudin-3 is expressed at theFrontiers in physiology · 2026
    Article
  2. Targeting P2X Receptors-Current Progress in Sepsis.International journal of inflammation · 2025
    Review
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

Eilidh CraigieCentre for Nephrology, University College London Medical School, London, United Kingdom.
Robert I MenziesBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Casper K LarsenDepartment of Biomedicine, Physiology, Aarhus University, Aarhus C, Denmark.
Grégory JacquilletCentre for Nephrology, University College London Medical School, London, United Kingdom.
Monique CarrelInstitue for Anatomy, University of Zürich, Zürich, Switzerland.
Scott S WildmanUrinary System Physiology Unit, Medway School of Pharmacy, University of Kent, Kent, United Kingdom.
Johannes LoffingInstitue for Anatomy, University of Zürich, Zürich, Switzerland.
Jens LeipzigerDepartment of Biomedicine, Physiology, Aarhus University, Aarhus C, Denmark.
David G ShirleyCentre for Nephrology, University College London Medical School, London, United Kingdom.
Matthew A BaileyBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-4244-5668
Robert J UnwinCentre for Nephrology, University College London Medical School, London, United Kingdom.ORCID 0000-0001-7839-6031
University of Zurich · CHAarhus University · DKBritish Heart Foundation · GBUniversity College London · GBAstraZeneca (Netherlands) · NLMedway School of Pharmacy · GB

Funding

British Heart Foundation FS/15/60/31510Wellcome TrustWellcome Trust WT087435MA
6 · The paper itself

Abstract

In the kidney, purinergic (P2) receptor-mediated ATP signaling has been shown to be an important local regulator of epithelial sodium transport. Appropriate sodium regulation is crucial for blood pressure (BP) control and disturbances in sodium balance can lead to hypo- or hypertension. Links have already been established between P2 receptor signaling and the development of hypertension, attributed mainly to vascular and/or inflammatory effects. A transgenic mouse model with deletion of the P2X4 receptor (P2X4

Indexed as

Blood PressureDiet, Sodium-RestrictedRenal ReabsorptionAnimalsEpithelial Sodium ChannelsHypertension, RenalKidneyMiceMice, Inbred C57BLReceptors, Purinergic P2X4SodiumEpithelial Sodium ChannelsReceptors, Purinergic P2X4SodiumENaChypertensionpurinergicpurinoceptorsalt-sensitivitysodium

Identifiers

PMID30350402
PMCPMC6198136
OpenAlexW2897747593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.