Evidence map›Paper›PMID 30350267›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019

The effect of renal transplantation on left ventricular function, electrocardiography, and mechanical synchrony by gated myocardial perfusion imaging.

William Crosland, Himanshu Aggarwal, Ayman Farag, Shikha Mehta, Roslyn B Mannon, Jaekyeong Heo, Ami E Iskandrian, Fadi G Hage

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

William CroslandDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Himanshu AggarwalDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Ayman FaragDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Shikha MehtaDivision of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
Roslyn B MannonDivision of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jaekyeong HeoDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Ami E IskandrianDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Fadi G HageDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA. fadihage@uab.edu.
University of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepressed left ventricular ejection fraction (LVEF), LV mechanical dyssynchrony (LVMD), and prolonged QTc interval predict poor outcomes in end-stage renal disease (ESRD). Renal transplantation improves mortality in ESRD patients but the effects of transplantation on these indices remain undefined.

methodsWe identified patients with myocardial perfusion imaging (MPI) before and after renal transplantation. A control group consisted of ESRD patients who underwent 2 MPIs but did not receive a transplant. Changes in LVEF, LVMD indices [phase standard deviation (SD) and bandwidth (BW)] by MPI, and electrocardiogram (ECG) indices were determined.

resultsThe study population consisted of 32 ESRD patients (53% male, 50 ± 11 years, 59% African American, 65% diabetic). The second MPI was performed 31 months (13-59 months) after renal transplantation. LVEF (72 ± 10% vs. 67 ± 10%, P < 0.001) but not SD (22 ± 15° vs. 22 ± 11°, P = 0.9) or BW (58 ± 35° vs. 57 ± 29°, P = 0.9) improved after transplantation. There were no changes in these indices in the control group. QTc (425 ± 30 ms vs. 447 ± 32 ms, P = <0.001) but not QRS (90 ± 21 ms vs. 90 ± 21 ms, P = 0.9) improved significantly after renal transplantation.

conclusionsLVEF and QTc improved after renal transplantation but LVMD indices and QRS did not change, which suggests that LVMD and electrical dyssynchrony may be irreversible in ESRD.

Indexed as

ElectrocardiographyKidney TransplantationMyocardial Perfusion ImagingTomography, Emission-Computed, Single-PhotonVentricular Function, LeftAdultCardiac-Gated Single-Photon Emission Computer-Assisted TomographyFemaleHeart VentriclesHumansKidney Failure, ChronicMaleMiddle AgedRetrospective StudiesTreatment OutcomeVentricular Dysfunction, LeftMyocardial biologyPhysiology of LV/RV functionPhysiology of myocardial/coronary perfusion

Identifiers

PMID30350267
OpenAlexW2897881713

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.