Evidence map›Paper›PMID 30350256›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019

Hemoglobin F as a predictor of health-related quality of life in children with sickle cell anemia.

Mohamed-Rachid Boulassel, Amira Al-Badi, Mohamed Elshinawy, Juhaina Al-Hinai, Muna Al-Saadoon, Zahra Al-Qarni, Hammad Khan, Rizwan Nabi Qureshi, Yasser Wali

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed-Rachid BoulasselDepartment of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. boulassel@squ.edu.om.
Amira Al-BadiDepartment of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Mohamed ElshinawyDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Juhaina Al-HinaiDepartment of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Muna Al-SaadoonDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Zahra Al-QarniDepartment of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Hammad KhanDepartment of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Rizwan Nabi QureshiDepartment of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Yasser WaliDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Funding

Sultan Qaboos University IG/MED/HAEM/14/01The Oman Research Council ORG/HSS/ 13/002
6 · The paper itself

Abstract

purposeAs treatment options for children with sickle cell anemia (SCA) continue to expand survival, evaluation of factors associated with health-related quality of life (HRQoL) is becoming an important aspect for further improving clinical management. Although the general features of SCA are similar, factors influencing HRQoL within a country may differ from those of other countries, therefore this study aimed to explore factors affecting HRQoL in children with SCA living in the Sultanate of Oman.

methodsThis was a cross-sectional study in which the PedsQL™ Sickle Cell Disease Module was used to evaluate the overall HRQoL in children with SCA. The socio-demographic data, clinical, and treatment outcomes were collected. Univariate and multivariate linear regression analyses were used to identify predictors of HRQoL.

resultsA total of 123 children with SCA, aged from 2 to 16 years were enrolled. The mean total HRQoL score was 52 ± 15% (9-94), where Worry II scale recorded the highest score. The multiple regression analysis revealed that the only predictors of total HRQoL score were hemoglobin F (B = 0.64, 95% confidence interval [CI] 0.149-1.118, P = 0.009) and to a lesser degree white blood cell count (B = - 0.99, 95% CI - 1.761 to - 0.198, P = 0.01), independently of other study parameters such as age, gender, spleen status, and hydroxyurea therapy.

conclusionsCollectively, these findings indicated that hemoglobin F out-weighted white blood cell count in predicting HRQoL in Omani children with SCA. Recognition of these factors could help health professionals to develop effective strategies to improve the overall HRQoL in these young patients.

Indexed as

AdolescentAnemia, Sickle CellChildChild, PreschoolCross-Sectional StudiesFemaleFetal HemoglobinHumansMaleQuality of LifeTreatment OutcomeFetal HemoglobinHemoglobin FPredictorQuality of lifeSickle cell anemia

Identifiers

PMID30350256

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