Evidence map›Paper›PMID 30350237›Full record

ArticleMolecular biology reports2019

Synthesis of terpenoid oxo derivatives with antiureolytic activity.

Agata Kozioł, Katarzyna Macegoniuk, Ewa Grela, Agnieszka Grabowiecka, Monika Biernat, Stanisław Lochyński

Abstract read
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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Agata KoziołBioorganic Chemistry Department, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.
Katarzyna MacegoniukBioorganic Chemistry Department, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.
Ewa GrelaBioorganic Chemistry Department, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.
Agnieszka GrabowieckaBioorganic Chemistry Department, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.
Monika BiernatDepartment and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wrocław Medical University, Wybrzeże Pasteura 4, 50-367, Wrocław, Poland.
Stanisław LochyńskiBioorganic Chemistry Department, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland. stanislaw.lochynski@pwr.edu.pl.
AGH University of Krakow · PLWrocław University of Science and Technology · PLWroclaw Medical University · PL

Funding

Wroclaw Centre of Biotechnology Program 2014-2018
6 · The paper itself

Abstract

Urease is an important virulence factor for a variety of pathogenic bacteria strains such as Helicobacter pylori, which colonizes human gastric mucosa, and Proteus sp., responsible for urinary tract infections. Specific inhibition of urease activity could be a promising adjuvant strategy for eradication of these pathogens. Due to the interesting antiureolytic activity of carvone and the scant information regarding the inhibitory properties of corresponding monoterpenes, we decided to study selected monoterpenic ketones and their oxygen derivatives. Several monoterpenes and their terpenoid oxygen derivatives were evaluated in vitro against Sporosarcina pasteurii urease. The most effective inhibitors-derivatives of β-cyclocitral (ester 10 and bromolactone 14)-were described with [Formula: see text] of 46.7 µM and 45.8 µM, respectively. Active inhibitors of native urease were tested against H. pylori and Proteus mirabilis whole cells. Here, the most active inhibitor, 14, was characterized with IC

Indexed as

AldehydesAnti-Bacterial AgentsDiterpenesEscherichia coliGastric MucosaHelicobacter pyloriHumansMonoterpenesPlant ExtractsSporosarcinaStaphylococcus aureusTerpenesUreaseUrinary Tract InfectionsAldehydesAnti-Bacterial Agentsbeta-cyclocitralDiterpenesMonoterpenesPlant ExtractsTerpenesUreaseAntiureolytic activityBacterial ureaseInhibitorsTerpenoid

Identifiers

PMID30350237
OpenAlexW2897860307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.