Evidence map›Paper›PMID 30350231›Full record

ArticleJournal of materials science. Materials in medicine2018

Fabrication of enzyme-responsive composite coating for the design of antibacterial surface.

Peng Liu, Yansha Hao, Yao Ding, Zhang Yuan, Yisi Liu, Kaiyong Cai

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peng LiuKey Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, 400044, Chongqing, China. liupeng79@cqu.edu.cn.
Yansha HaoKey Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, 400044, Chongqing, China.
Yao DingKey Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, 400044, Chongqing, China.
Zhang YuanKey Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, 400044, Chongqing, China.
Yisi LiuKey Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, 400044, Chongqing, China.
Kaiyong CaiKey Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, 400044, Chongqing, China. kaiyong_cai@cqu.edu.cn.

Funding

Chongqing Research Program of Technological Innovation and Application Demonstration Project No. cstc2018jscx-msybX0299Fundamental Research Funds for the Central Universities Project No. 2018CDXYSW0023Innovation Team in University of Chongqing Municipal Government Project No. CXTDX201601002National Natural Science Foundation of China Grant No. 51303218National Natural Science Foundation of China Grant Nos. 51673032 and 21734002State Key Project of Research and Development Grant No. 2016YFC1100300
6 · The paper itself

Abstract

In this study, a type of bacteria enzyme-triggered antibacterial surface with a controlled release of Ag ions was developed. Firstly, chitosan-silver nanocomposites (Chi@Ag NPs) were in situ synthesized via using ascorbic acid as reducing agent. Chi@Ag NPs were characterized by transmission electron microscopy, ultraviolet-visible spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy. Subsequently, Chi@Ag NPs and hyaluronic acid (HA) were used to fabricate antibacterial composite coating via Layer-by-Layer (LBL) self-assembly method. The successful construction of Chi@Ag NPs/HA composite coating was confirmed by scanning electron microscopy, energy dispersive spectroscopy and contact angle measurements, respectively. Then, the amount of released Ag ion was analyzed by inductively coupled plasma atomic emission spectrometry, which demonstrated that the release of Ag ions from the surface could be triggered by enzyme (e.g. hyaluronidase). A series of antibacterial tests in vitro, including zone of inhibition test, bacterial viability assay, antibacterial rate measurement and bacteria adhesion observation, demonstrated that the enzyme-responsive surface could inhibit the growth of bacteria. On the whole, this study provides an alternative approach for the fabrication of antibacterial surfaces on synthetic materials in various fields with the minimal side effects on surrounding environment and human body.

Indexed as

Anti-Bacterial AgentsBone SubstitutesCalcium PhosphatesCoated Materials, BiocompatibleCollagenGelatinMicroscopy, Electron, ScanningNanocompositesSurface PropertiesTensile StrengthAnti-Bacterial AgentsBone SubstitutesCalcium PhosphatesCoated Materials, BiocompatibleCollagenGelatin

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.