Evidence map›Paper›PMID 30350189›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature.

Jennifer A Soon, Angelyn Anton, Javier Torres, Ruth Lawrence, Phillip Parente, Joseph McKendrick, Ian D Davis, Carmel Pezaro

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Men's experiences of surviving testicular cancer: an integrated literature review.Journal of cancer survivorship : research and practice · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jennifer A SoonEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.
Angelyn AntonEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.
Javier TorresEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.
Ruth LawrenceEastern Health Library Services, 5 Arnold St., Box Hill, VIC, 3128, Australia.
Phillip ParenteEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.
Joseph McKendrickEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.
Ian D DavisEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia.
Carmel PezaroEastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia. carmel.pezaro@monash.edu.ORCID http://orcid.org/0000-0002-9033-5626
Eastern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTesticular seminomas occur in young men and are highly curable. Toxicities following treatment for men with extensive stage II-III seminomas may cause long-term morbidities. However, it is not clear whether the risk of late effects also increases following surgery for testis-confined seminoma. In this systematic review, we examined the available literature regarding the incidence of late effects in our target population of patients with stage I seminoma treated with orchidectomy alone.

methodPublications were identified through an electronic literature search using the MEDLINE, EMBASE and PsychInfo databases, identifying cohorts treated for stage I seminoma. Data on late effects were collected and classified as physical or psychological.

resultsSix hundred and four articles were screened to identify 100 studies. In the target population, available evidence suggests no increased risk of cardiovascular disease, metabolic syndrome, or renal dysfunction compared to the general population. Sperm counts were initially lower than an age-matched cohort; however, counts normalised when re-assessed 5 years later. Data were not specifically reported for the target population regarding bone health, second malignancy, hypogonadism, fertility and all psychological domains. Heterogeneity of study design and reporting methods contributed to uncertainty regarding the true incidence and clinical significance of late effects.

conclusionsThe curability of stage I seminoma and the wide range of potential late effects of treatment suggest the need for long-term monitoring alongside standard cancer surveillance. Important data are needed on the prevalence of late effects, specifically related to testicular cancer survivors undergoing surveillance following orchidectomy. IMPLICATIONS FOR CANCER SURVIVORS: Awareness and screening for relevant late effects may prevent further morbidity in men treated for stage I seminoma.

Indexed as

Disease ProgressionFemaleHumansMaleNeoplasm StagingOrchiectomySeminomaTesticular NeoplasmsGerm cell tumourLate effectsSeminomaSurvivorshipSystematic reviewTesticular cancer

Identifiers

PMID30350189
OpenAlexW2896774465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.