SynthesisJournal of neurology2019
Biological and imaging predictors of cognitive impairment after stroke: a systematic review.
Synthesis in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review.Brain imaging and behavior · 2025Pooled it
- Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2022Pooled it
- Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Circulating MicroRNAs as Diagnostic Biomarkers of Clinical Cognitive Impairment: A Meta-Analysis.American journal of Alzheimer's disease and other dementiasPooled it
- Mechanisms and biomarkers of poststroke cognitive impairment.Neural regeneration research · 2026Article
- Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026Review
- Imaging research, diagnosis, and treatment advances of post-stroke cognitive impairment.Frontiers in neuroimaging · 2026Review
- Role of Electroencephalographic Biomarkers as Predictors of Post-Stroke Cognitive Outcomes in Patients with Cerebral Infarction: Literature Review.Neuropsychiatric disease and treatment · 2026Review
- The immunology of stroke and dementia.Immunity · 2025Review
- Post-stroke cognitive impairment: More than a lesion-symptom model.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spinal cord electrical stimulation for severe disturbance of consciousness after traumatic brain injury: A case report.Heliyon · 2024Article
- Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study.BMC neurology · 2024Article
- Nonlinear relationship between triglycerides and cognitive function after acute ischemic stroke among older adults.Heliyon · 2024Article
- Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention.Frontiers in molecular neuroscience · 2024Review
- Association of Income with Post-Stroke Cognition and the Underlying Neuroanatomical Mechanism.Brain sciences · 2023Article
- Gamma-glutamyl transferase levels are associated with the occurrence of post-stroke cognitive impairment: a multicenter cohort study.BMC neurology · 2022Article
- Neuroimaging biomarkers of cognitive recovery after ischemic stroke.Frontiers in neurology · 2022Review
- Longitudinal Brain Changes After Stroke and the Association With Cognitive Decline.Frontiers in neurology · 2022Article
- Evaluation of White Matter Microstructural Alterations in Patients with Post-Stroke Cognitive Impairment at the Sub-Acute Stage.Neuropsychiatric disease and treatment · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCognitive impairment is frequent after stroke, and several studies have suggested that biological and imaging characteristics present before stroke are associated with the development of post-stroke cognitive impairment.
objectiveThe aim of our study was to systematically review biological and imaging predictors of cognitive impairment after stroke.
methodStudies were identified from bibliographic databases and reference lists, and were included if conducted in patients with acute stroke, with at least 30 patients, and a follow-up of at least 3 months. We included articles on potential biomarkers of cognitive impairment that pre-existed to stroke.
resultsWe identified 22,169 articles, including 20,349 with abstract. After analysis, 66 studies conducted in 42 cohorts met selection criteria. They included 30-9522 patients [median 170; interquartile range (IQR) 104-251] with a median follow-up of 12 months (IQR 3-36). All studies met quality criteria for description of the study population and standardization of biomarkers. Twenty-nine studies met all quality criteria. There was no convincing evidence that any biological marker may predict cognitive impairment. The most consistent predictors of cognitive impairment after stroke were global atrophy and medial temporal lobe atrophy.
conclusionPre-existing cerebral atrophy is the most consistent predictor of cognitive impairment that can be identified in patients with an acute stroke.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.