Evidence map›Paper›PMID 30350153›Full record

Trial reportEuropean journal of applied physiology2019

Changes of blood pressure following initiation of physical inactivity and after external addition of pulses to circulation.

Marvin A Sackner, Shivam Patel, Jose A Adams

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05569122 (The Utility of pGz in Primary Mitochondrial Disorders), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05569122 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

The Utility of pGz in Primary Mitochondrial Disorders

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2023 to 2028Enrolled90ConditionsMitochondrial Myopathies, Mitochondrial DiseasesArmsCardiopulmonary Exercise Testing, pGz Bed, Gentle Jogger, Exercise Pedal, Lumason® contrast agent
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marvin A SacknerEmeritus Director of Medical Services, Mt Sinai Medical Center of Greater Miami, Miami Beach, FL, USA.
Shivam PatelUniversity of Miami, Coral Gables, FL, USA.
Jose A AdamsDivision Neonatology, Mt Sinai Medical Center of Greater Miami, Miami Beach, FL, USA. Tony.Adams@msmc.com.ORCID http://orcid.org/0000-0002-9401-2226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether an innovative, motorized, wellness device that effortlessly produces physical activity (JD) can mitigate the hypertensive effects of prolonged sitting or lying down.

methodsTwenty-two normotensive and hypertensive adults of both genders gave informed consent to participate in a randomized controlled crossover study of a passive simulated jogging device (JD) in both supine and seated postures. Each study participant was monitored with a continuous non-invasive arterial pressure monitoring device (CNAP) over 60 min. The initial 10 min served as baseline for each posture. The subjects were randomized to begin with either JD or SHAM control for 30 min, and monitoring was continued for an additional 10 min in one posture; three days later posture and order of JD or SHAM were changed.

resultsIn both seated and supine postures, SHAM was associated with a significant rise in blood pressure (BP) which was observed within 5-10 min; it continued to rise or remain elevated for over a 40-min observation period. In contrast, JD produced a significant decrease in both systolic and diastolic blood pressure in both postures. During recovery in seated posture JD decreased systolic and diastolic BP by - 8.1 and - 7.6 mmHg, respectively. In supine posture, a similar decrease in BP occurred.

conclusionsThere is rapid onset of increase in systolic and diastolic BP with physical inactivity in both supine and seated postures. Administration of JD significantly decreased BP in both postures. Further studies are needed to assess long-term effectiveness.

Indexed as

Blood PressureAdultBed RestExercise TherapyFemaleHumansHypertensionImmobilizationMaleMiddle AgedSupine PositionBlood pressurePhysical inactivityPreventionPulsatile shear stressWellness

Identifiers

PMID30350153
PMCPMC6342894

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.