ArticleResearch and practice in thrombosis and haemostasis2018
Serial imaging after pulmonary embolism and correlation with functional limitation at 12 months: Results of the ELOPE Study.
Article in Research and practice in thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 44 citations in OpenAlex.
- One-Year Echocardiographic, Functional, and Quality of Life Outcomes After Ultrasound-Facilitated Catheter-Based Fibrinolysis for Pulmonary Embolism.Circulation. Cardiovascular interventions · 2020Trial
- Evaluation of Predisposing Factors and Coexisting Diseases in the Development of Chronic Thromboembolic Pulmonary Disease.The clinical respiratory journal · 2025Article
- How I treat pediatric pulmonary embolism.Blood · 2025Review
- Is pulmonary embolism a chronic disease?Clinical medicine (London, England) · 2025Review
- Article
- The Aftermath of Pulmonary Embolism: Are Residual Thrombi Clinically Significant?Diagnostics (Basel, Switzerland) · 2025Review
- Cardiopulmonary exercise testing following acute pulmonary embolism: Systematic review and pooled analysis of global studies.Pulmonary circulation · 2024Article
- Pulmonary perfusion defects or residual vascular obstruction and persistent symptoms after pulmonary embolism: a systematic review and meta-analysis.ERJ open research · 2024Article
- Practice Variations in the Diagnosis and Treatment of Pulmonary Embolism.Pulmonary medicine · 2024Article
- Cardiopulmonary exercise testing during follow-up after acute pulmonary embolism.The European respiratory journal · 2023Article
- Feasibility of monitoring the resolution of acute pulmonary embolism with non-contrast-enhanced magnetic resonance imaging at one day, one week, one, three, and six months.Acta radiologica (Stockholm, Sweden : 1987) · 2023Article
- Usefulness of a refined computed tomography imaging method to assess the prevalence of residual pulmonary thrombi in patients 1 year after acute pulmonary embolism: The Nagoya PE study.Journal of thrombosis and haemostasis : JTH · 2022Article
- Article
- Serial imaging after pulmonary embolism and correlation with functional limitation at 12 months: Results of the ELOPE Study.Research and practice in thrombosis and haemostasis · 2018Article
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Authors and funding
19 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRisk factors for exercise limitation after acute pulmonary embolism (PE) are unknown. As a planned sub-study of the prospective, multicenter ELOPE (Evaluation of Long-term Outcomes after PE) Study, we aimed to describe the results of serial imaging by computed tomography pulmonary angiography (CTPA) and perfusion scan during 1 year after a first episode of acute pulmonary embolism, and to assess the association between imaging parameters and exercise limitation at 1 year.
methodsIn a prospective cohort study, 100 patients were recruited between June 2010 and February 2013 at five Canadian university-affiliated hospitals. CT pulmonary angiography was performed at baseline and 12 months, perfusion scan at 6 and 12 months, and cardio-pulmonary exercise testing at 1 and 12 months. Imaging parameters included: on CT pulmonary angiography, CT obstruction index (CTO) (% clot burden in the pulmonary vasculature), and on perfusion scan, pulmonary vascular obstruction (PVO) (% perfusion defect). Abnormal cardio-pulmonary exercise test (primary outcome) was defined as percent of predicted peak oxygen uptake (VO2) <80%.
resultsMean (median; SD) CT obstruction index was 28.1% (27.5%; 18.3%) at baseline, 1.2% (0%; 4.3%) at 12 months. Mean (median; SD) pulmonary vascular obstruction was 6.0% (0%; 9.6%) at 6 months, 5.6% (0%; 9.8%) at 12 months. Eighty-six patients had exercise testing at 12 months, and 46.5% had VO2 < 80% predicted. Mean (median; SD) CT obstruction index at 1 year was similar in patients with percent-predicted VO2 peak <80% vs >80% on 1-year cardio-pulmonary exercise testing (1.4% [0%; 5.7%] vs 1.0% [0%; 2.4%];
conclusionsImaging findings after pulmonary embolism did not predict exercise limitation. Residual thrombus does not appear to explain long-term functional limitation after pulmonary embolism.
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