Evidence map›Paper›PMID 30349873›Full record

ArticleACS biomaterials science & engineering2018

Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury.

Kristin P O'Grady, Taylor E Kavanaugh, Hongsik Cho, Hanrong Ye, Mukesh K Gupta, Megan C Madonna, Jinjoo Lee, Christine M O'Brien, Melissa C Skala, Karen A Hasty and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 60 citations in OpenAlex.

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  19. Microsphere antioxidant and sustained erythropoietin-R76E release functions cooperate to reduce traumatic optic neuropathy.Journal of controlled release : official journal of the Controlled Release Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kristin P O'GradyBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Taylor E KavanaughBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Hongsik ChoOrthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research Service 151, VA Medical Center, 1030 Jefferson Avenue, Memphis, Tennessee 38104, United States.
Hanrong YeBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Mukesh K GuptaBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Megan C MadonnaBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Jinjoo LeeBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Christine M O'BrienBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Melissa C SkalaBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Karen A HastyOrthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research Service 151, VA Medical Center, 1030 Jefferson Avenue, Memphis, Tennessee 38104, United States.
Craig L DuvallBiomedical Engineering, Vanderbilt University, 1225 Stevenson Center Lane, 5824 Stevenson Center, Nashville, Tennessee 37235, United States.
Stevenson University · USUniversity of Tennessee Health Science Center · US

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Quantitative In Vivo Optical Imaging of Vascular Response to Hind Limb IschemiaR21HL109748 · NHLBI · VANDERBILT UNIVERSITY · PI DUVALL, CRAIG LEWIS, SKALA, MELISSA CAROLINE · 2012 to 2013
$396k
NHLBI NIH HHS R21 HL109748NIBIB NIH HHS T32 EB001628
6 · The paper itself

Abstract

The inherent antioxidant function of poly(propylene sulfide) (PPS) microspheres (MS) was dissected for different reactive oxygen species (ROS), and therapeutic benefits of PPS-MS were explored in models of diabetic peripheral arterial disease (PAD) and mechanically induced post-traumatic osteoarthritis (PTOA). PPS-MS (∼1

Indexed as

diabetesinflammationmicrospheresosteoarthritisperipheral arterial diseasereactive oxygen species

Identifiers

PMID30349873
PMCPMC6195321
OpenAlexW2605118946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.