ArticleAnnals of clinical and translational neurology2018
NeurEx: digitalized neurological examination offers a novel high-resolution disability scale.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04496830 (Cerebrospinal Fluid-biomarkers-based Diagnostic and Prognostic Models for Multiple Sclerosis), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cerebrospinal Fluid-biomarkers-based Diagnostic and Prognostic Models for Multiple Sclerosis
Who cites it
20 citing papers in PubMed.
- Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.The Journal of clinical investigation · 2025Trial
- Trial
- From Diagnosis to Disease Staging: Multisite Validation of Cerebrospinal Fluid Molecular Tests in Multiple Sclerosis.Annals of neurology · 2026Article
- Assessing verbal and spatial memory via smartphone.Frontiers in digital health · 2026Article
- Longitudinal proteomic profiling of cerebrospinal fluid in untreated multiple sclerosis defines evolving disease biology.Nature communications · 2025Article
- Smartphone postural sway and pronator drift tests as measures of neurological disability.BMC neurology · 2025Article
- Medical Digital Twin: A Review on Technical Principles and Clinical Applications.Journal of clinical medicine · 2025Review
- Measuring neurological severity and complexity in acute setting: the modified Neurological Impairment Scale.BMJ neurology open · 2025Article
- Smartphone Postural Sway and Pronator Drift tests as Measures of Neurological Disability.medRxiv : the preprint server for health sciences · 2024Article
- A Delphi consensus to identify the key screening tests/questions for a digital neurological examination for epidemiological research.Journal of neurology · 2024Article
- Smartphone tests quantify lower extremities dysfunction in multiple sclerosis.Frontiers in neurology · 2024Article
- Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms.Nature communications · 2022Article
- Confounder-adjusted MRI-based predictors of multiple sclerosis disability.Frontiers in radiology · 2022Article
- Smartphone-based symbol-digit modalities test reliably captures brain damage in multiple sclerosis.NPJ digital medicine · 2021Article
- Assessment of Smartphone-Based Spiral Tracing in Multiple Sclerosis Reveals Intra-Individual Reproducibility as a Major Determinant of the Clinical Utility of the Digital Test.Frontiers in medical technology · 2021Article
- Digital Twins for Multiple Sclerosis.Frontiers in immunology · 2021Review
- Extensive Healthy Donor Age/Gender Adjustments and Propensity Score Matching Reveal Physiology of Multiple Sclerosis Through Immunophenotyping.Frontiers in neurology · 2020Article
- Data Collection in Multiple Sclerosis: The MSDS Approach.Frontiers in neurology · 2020Article
- Smartphone Level Test Measures Disability in Several Neurological Domains for Patients With Multiple Sclerosis.Frontiers in neurology · 2019Article
- Identifying and Quantifying Neurological Disability via Smartphone.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo develop a sensitive neurological disability scale for broad utilization in clinical practice.
methodsWe employed advances of mobile computing to develop an iPad-based App for convenient documentation of the neurological examination into a secure, cloud-linked database. We included features present in four traditional neuroimmunological disability scales and codified their automatic computation. By combining spatial distribution of the neurological deficit with quantitative or semiquantitative rating of its severity we developed a new summary score (called NeurEx; ranging from 0 to 1349 with minimal measurable change of 0.25) and compared its performance with clinician- and App-computed traditional clinical scales.
resultsIn the cross-sectional comparison of 906 neurological examinations, the variance between App-computed and clinician-scored disability scales was comparable to the variance between rating of the identical neurological examination by multiple sclerosis (MS)-trained clinicians. By eliminating rating ambiguity, App-computed scales achieved greater accuracy in measuring disability progression over time (
interpretationNeurEx can be used as a highly sensitive outcome measure in neuroimmunology. The App can be easily modified for use in other areas of neurology and it can bridge private practice practitioners to academic centers in multicenter research studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.