ArticleAnnals of clinical and translational neurology2018
Effect of smoking cessation on the risk of dementia: a longitudinal study.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Distinct sex-specific DNA methylation differences in Alzheimer's disease.Alzheimer's research & therapy · 2022Pooled it
- How are people with mild cognitive impairment or subjective memory complaints managed in primary care? A systematic review.Family practice · 2021Pooled it
- Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies.BMJ (Clinical research ed.) · 2021Pooled it
- Association Between Visual Impairment and Depression in Patients Attending Eye Clinics: A Meta-analysis.JAMA ophthalmology · 2021Pooled it
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Smoking cessation duration and risk of Alzheimer's disease: a nationwide cohort study in Korea.Alzheimer's research & therapy · 2026Article
- Association of Healthy Lifestyle with Insomnia Among Chinese Older Adults: A Cross-Sectional Study.Clocks & sleep · 2026Article
- Review
- Exploring the Research Progress of Vascular Dementia and Key Regulatory Molecules: E2F1.International journal of molecular sciences · 2026Review
- Projected Cognitive and Brain Aging Benefits of Eliminating Cardiometabolic Risks in Non-Hispanic White and Black Males - HABS-HD.Journal of racial and ethnic health disparities · 2026Article
- Accelerating real-world prediction and research in Alzheimer's: The M3AD study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Physical Activity with Dementia Risk in Cancer Survivors: A Korean Nationwide Cohort Study.Cancer research and treatment · 2026Article
- Smoking is associated with increased risk for dementia: the HUNT study, Norway.BMC public health · 2025Article
- Smoking Cessation, Weight Change, and Risk of Dementia: A Prospective Cohort Study.medRxiv : the preprint server for health sciences · 2025Article
- Psychiatry meets neurodegeneration - A collaborative approach to dementia prevention.The journal of prevention of Alzheimer's disease · 2025Article
- Updates on vascular dementia.Stroke and vascular neurology · 2025Review
- The Impact of Cognitive Impairment on Cardiovascular Disease.Journal of the American College of Cardiology · 2025Review
- Burden of risk factors attributable to Alzheimer's disease and other dementia and its relationship with the Socio-Demographic index in Asia.BMC neurology · 2025Article
- Oral diadochokinesis performance correlates with mild cognitive impairment: a cross-sectional study.BMC oral health · 2025Article
- DNA methylation signature of a lifestyle-based resilience index for cognitive health.Alzheimer's research & therapy · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the risk of developing dementia in relation to duration of smoking cessation by using a nationwide health claims database.
methodsThis cohort study included 46,140 men aged 60 years or older from Korean National Health Insurance System - National Health Screening Cohort, a population-based national health screening program from 2002 to 2013. The changes in smoking habit from a questionnaire during the first (2002 and 2003) and second (2004 and 2005) health examination periods, participants were divided into continual smokers, short-term (less than 4 years) quitters, long-term (4 years or more) quitters, and never smokers. Participants were followed-up for 8 years from January 1, 2006 for the development of overall dementia, Alzheimer's disease, and vascular dementia.
resultsCompared to continual smokers, long-term quitters and never smokers had decreased risk of overall dementia (hazard ratio, HR 0.86 95% CI, confidence interval 0.75-0.99 and HR: 0.81; 95% CI: 0.71-0.91, respectively). Never smokers had decreased risk of Alzheimer's disease (HR: 0.82; 95% CI: 0.70-0.96) compared to continual smokers. Finally, both long-term quitters (HR: 0.68; 95% CI: 0.48-0.96) and never smokers (HR: 0.71; 95% CI: 0.54-0.95) had decreased risk of vascular dementia compared to continual smokers.
interpretationSmoking was associated with increased risk of dementia. Smokers who quit for a prolonged period of time may benefit from reduced risk of dementia. Therefore, smokers should be encouraged to quit in order to reduce the risk of developing dementia, especially in the elderly population who are already at risk.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.