ArticleOpen forum infectious diseases2017
Sequential Gastroenteritis Outbreaks in a Single Year Caused by Norovirus Genotypes GII.2 and GII.6 in an Institutional Setting.
Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of infection control measures and norovirus outbreak outcomes in healthcare settings: a systematic review and meta-analysis.Expert review of anti-infective therapy · 2022Pooled it
- Characterization of humoral and cellular immunity induced by mRNA vaccines expressing norovirus VP1 proteins in mice and NHPs.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Mechanisms of Norovirus Immunity: Implications for Vaccine Design.Annual review of pathology · 2026Review
- The saga to monitor and control norovirus: the rise of GII.17.The Journal of general virology · 2025Review
- A narrative review of norovirus epidemiology, biology, and challenges to vaccine development.NPJ vaccines · 2024Review
- Serological surveillance of GI norovirus reveals persistence of blockade antibody in a Jidong community-based prospective cohort, 2014-2018.Frontiers in cellular and infection microbiology · 2023Article
- Cross-reactive neutralizing human monoclonal antibodies mapping to variable antigenic sites on the norovirus major capsid protein.Frontiers in immunology · 2022Article
- Prevalence and Evolution of Noroviruses between 1966 and 2019, Implications for Vaccine Design.Pathogens (Basel, Switzerland) · 2021Article
- Acute gastroenteritis outbreaks in closed and semi-closed facilities during 2017 in Catalonia, Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Characterization of a hospital-based gastroenteritis outbreak caused by GII.6 norovirus in Jinshan, China.Epidemiology and infection · 2020Article
- The effect of proteolytic enzymes and pH on GII.4 norovirus, during both interactions and non-interaction with Histo-Blood Group Antigens.Scientific reports · 2020Article
- Characterization of Antigenic Relatedness Among GI Norovirus Genotypes Using Serum Samples From Norovirus-Infected Patients and Mouse Sera.Frontiers in microbiology · 2020Article
- Virus-Host Interactions Between Nonsecretors and Human Norovirus.Cellular and molecular gastroenterology and hepatology · 2020Article
- Prevalence of noroviruses in children hospitalized for acute gastroenteritis in Hohhot, China, 2012-2017.BMC infectious diseases · 2019Article
- Norovirus Attachment and Entry.Viruses · 2019Review
- Norovirus disease among older adults.Therapeutic advances in infectious diseaseReview
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNorovirus is a leading cause of acute gastroenteritis worldwide. Improved diagnostic capability has been instrumental in the characterization of archival norovirus strains associated with gastroenteritis outbreaks that were investigated decades ago. One such investigation was that of 2 sequential gastroenteritis outbreaks that occurred in 1971 at the former Henryton State Hospital in Maryland. Approximately 40% of the resident population experienced clinical symptoms in both outbreaks, which occurred 11 months apart.
methodsStored stools and paired sera were re-analyzed to investigate the etiology of the 2 outbreaks.
resultsDifferent norovirus genotypes were identified as the etiological agents responsible for the illnesses, with GII.2 associated with the first outbreak and GII.6 with the second. The viruses were antigenically distinct as determined by analyses of hyperimmune sera raised against the corresponding virus-like particles in animals, as well as paired sera from infected individuals.
conclusionsThe observed antigenic differences were consistent with the failure of the GII.2 strain to provide cross-protective immunity to the GII.6 strain a few months later. An understanding of antigenic diversity among norovirus genotypes will be important in the design of norovirus vaccines.
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