ReviewEuropean endocrinology2018
Male Central Hypogonadism in Paediatrics - the Relevance of Follicle-stimulating Hormone and Sertoli Cell Markers.
Review in European endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Gonadotropin Therapy for Mini-Puberty Induction in Male Infants With Hypogonadotropic Hypogonadism.The Journal of clinical endocrinology and metabolism · 2025Pooled it
- Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone.Human reproduction (Oxford, England) · 2020Trial
- Gonadotropins in Mini-Puberty: Pathophysiological and Therapeutic Implications for Male Congenital Hypogonadism.Children (Basel, Switzerland) · 2026Review
- Testicular Volume of 4 mL Is Not an Appropriate Marker of Pubertal Onset in a Subset of Boys Born Small for Gestational Age.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2026Article
- Clinical approach to the male with delayed puberty.Archives of endocrinology and metabolism · 2025Review
- A Current Perspective on Delayed Puberty and Its ManagementJournal of clinical research in pediatric endocrinology · 2024Review
- Markers of Fertility in Adolescents With Chronic Endocrinopathies at Transition From Paediatric to Adult Care.Endocrinology, diabetes & metabolism · 2024Article
- Diagnosing and treating anterior pituitary hormone deficiency in pediatric patients.Reviews in endocrine & metabolic disorders · 2024Review
- Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG.Endocrinology · 2023Article
- Steroid receptors in the testis: implications in the physiology of prenatal and postnatal development and translation to clinical application.Histology and histopathology · 2023Review
- [Puberty induction in boys with congenital isolated hypogonadotropic hypogonadism].Problemy endokrinologii · 2023Article
- Revisiting the gonadotropic regulation of mammalian spermatogenesis: evolving lessons during the past decade.Frontiers in endocrinology · 2023Review
- Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism.The Journal of clinical endocrinology and metabolism · 2022Article
- Review of the Function of the Hypothalamic-Pituitary-Gonadal Axis in Children and Adolescents with Cancer.TouchREVIEWS in endocrinology · 2022Review
- Biomarkers of male hypogonadism in childhood and adolescence.Advances in laboratory medicine · 2020Review
- Review
- Paediatric and adult-onset male hypogonadism.Nature reviews. Disease primers · 2019Review
- Early Identification of Isolated Sertoli Cell Dysfunction in Prepubertal and Transition Age: Is It Time?Journal of clinical medicine · 2019Article
- Treatment of gonadotropin deficiency during the first year of life: long-term observation and outcome in five boys.Human reproduction (Oxford, England) · 2019Article
- Androgen Treatment in Adolescent Males With Hypogonadism.American journal of men's healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The definition of male hypogonadism, used in adult endocrinology, is not fully applicable to paediatrics. A clear understanding of the developmental physiology of the hypothalamic-pituitary-testicular axis is essential for the comprehension of the pathogenesis of hypogonadal states in boys and for the establishment of adequate definitions and classifications in paediatric ages. This is particularly true for central hypogonadism, usually called hypogonadotropic in adults. Because childhood is a period characterised by a physiological state of low gonadotropin and testosterone production, these markers of hypogonadism, typically used in adult endocrinology, are uninformative in the child. This review is focused on the physiological importance of prepubertal Sertoli cell markers - anti-Müllerian hormone (AMH) and inhibin B - and of the intratesticular actions of follicle-stimulating hormone (FSH) and testosterone during early infancy and the first stages of pubertal development. We discuss the role of FSH in regulating the proliferation of Sertoli cells - the main determinant of prepubertal testicular volume - and the secretion of AMH and inhibin B. We also address how intratesticular testosterone concentrations have different effects on the seminiferous tubule function in early infancy and during pubertal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.