Evidence map›Paper›PMID 30349541›Full record

ArticleFrontiers in immunology2018

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b.

Sebastian Peer, Giuseppe Cappellano, Natascha Hermann-Kleiter, Karin Albrecht-Schgoer, Reinhard Hinterleitner, Gottfried Baier, Thomas Gruber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. A catalog of GWAS fine-mapping efforts in autoimmune disease.American journal of human genetics · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sebastian PeerDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Giuseppe CappellanoDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Natascha Hermann-KleiterDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Karin Albrecht-SchgoerDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Reinhard HinterleitnerDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Gottfried BaierDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Thomas GruberDivision of Translational Cell Genetics, Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATUniversität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies as well as lymphatic expression analyses have linked both Cbl-b and GM-CSF to human multiple sclerosis as well as other autoimmune diseases. Both Cbl-b and GM-CSF have been shown to play a prominent role in the development of murine encephalomyelitis; however, no functional connection between the two has yet been established. In this study, we show that

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAutoimmunityCD4-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalGene Expression RegulationGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-3Mice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticProto-Oncogene Proteins c-cblAdaptor Proteins, Signal TransducingCblb protein, mouseGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-3Proto-Oncogene Proteins c-cbladaptive immunityCbl-bexperimental autoimmune encephalomyelitisGM-CSFmultiple sclerosis

Identifiers

PMID30349541
PMCPMC6186797
OpenAlexW2897995465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.