Evidence map›Paper›PMID 30349427›Full record

ArticleAdvanced functional materials2017

Thermogelling, ABC Triblock Copolymer Platform for Resorbable Hydrogels with Tunable, Degradation-Mediated Drug Release.

Mukesh K Gupta, John R Martin, Bryan R Dollinger, Madison E Hattaway, Craig L Duvall

Abstract read
In one paragraph

Article in Advanced functional materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Immunotherapies for locally aggressive cancers.Advanced drug delivery reviews · 2024
    Review
  9. Article
  10. Article
  11. Poly(Gels (Basel, Switzerland) · 2022
    Review
  12. A BRD4 PROTAC nanodrug for glioma therapyActa pharmaceutica Sinica. B · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Diflunisal-loaded poly(propylene sulfide) nanoparticles decrease S. aureus-mediated bone destruction during osteomyelitis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  18. Microsphere antioxidant and sustained erythropoietin-R76E release functions cooperate to reduce traumatic optic neuropathy.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mukesh K GuptaDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
John R MartinDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Bryan R DollingerDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Madison E HattawayDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Craig L DuvallDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.

Funding

Substrate Mediated siRNA Delivery from Scaffolds to Promote Wound RepairR01EB019409 · NIBIB · VANDERBILT UNIVERSITY · PI Craig Lewis Duvall · 2014 to 2026
$4.0M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
NIBIB NIH HHS R01 EB019409NIDDK NIH HHS T32 DK101003
6 · The paper itself

Abstract

Clinical application of injectable, thermoresponsive hydrogels is hindered by lack of degradability and controlled drug release. To overcome these challenges, a family of thermoresponsive, ABC triblock polymer-based hydrogels has been engineered to degrade and release drug cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated by the "A" block composition. Three ABC triblock copolymers are synthesized with varying "A" blocks, including oxidation-sensitive poly(propylene sulfide), slow hydrolytically/enzymatically degradable poly(ε-caprolactone), and fast hydrolytically/enzymatically degradable poly(D,L-lactide-

Indexed as

controlled drug releasehydrolytic degradationinjectable thermoresponsive biomaterialsin situ forming hydrogelsreactive oxygen species (ROS) responsive polymer

Identifiers

PMID30349427
PMCPMC6195316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.