ArticleClinical epidemiology2018
Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- FROM DISCOVERY SCIENCE TO THE CLINIC - HERITABLE ENDOCRINE CANCERS AND RELATED DISORDERS: Functional imaging in hereditary endocrine neoplasms: evolving modalities and clinical implications.Endocrine-related cancer · 2026Review
- Population Prevalence of the Major Thyroid Cancer-Associated Syndromes.The Journal of clinical endocrinology and metabolism · 2025Article
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- Abnormal uptake related to the thyroid gland on somatostatin receptor-targeted PET imaging: reported prevalence and rate of thyroid malignancy and parathyroid adenomas.Endocrine connections · 2024Article
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- Multiple endocrine neoplasia type 4: a new member of the MEN family.Endocrine connections · 2023Article
- Late-Onset Medullary Thyroid Cancer in a Patient with a GermlineDiagnostics (Basel, Switzerland) · 2021Article
- GermlineFrontiers in endocrinology · 2021Article
- Primary hyperparathyroidism as first manifestation in multiple endocrine neoplasia type 2A: an international multicenter study.Endocrine connections · 2020Article
- Preimplantation Genetic Testing of Multiple Endocrine Neoplasia Type 2A.Frontiers in endocrinology · 2020Article
- Variability in Medullary Thyroid Carcinoma inFrontiers in endocrinology · 2020Article
- Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997-2014: A Nationwide Study.Thyroid : official journal of the American Thyroid Association · 2019Article
- Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.Endocrine connections · 2019Article
- Completeness ofClinical epidemiology · 2019Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence.
methodsThis study included 250 unique MEN2A patients born or resident in Denmark before December 31, 2014. Patients were identified through the Danish
resultsThe incidence from 1971 to 2000 was 28 (95% CI: 21-37) per million live births per year. Incidence for the specific mutations or for the overall MEN2A group did not change significantly from 1901 to 2014 (
conclusionThe incidence and prevalence of MEN2A in Denmark seem higher than those reported in other countries. This is likely explained by the Danish C611Y founder effect. Also, our data indicate no significant change in MEN2A incidence during the last century.
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