ArticleClinical epidemiology2018
Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Familial and genetic overlap between Sjögren's disease and other autoimmune diseases.Frontiers in immunology · 2026Pooled it
- Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2020Pooled it
- Health care providers' perceptions of screening for risk of type 1 diabetes in newborns using genetic risk scores.Journal of community genetics · 2026Article
- Prevalence, Clinical, and Immunological Features of Familial Type 1 Diabetes Among Children and Adolescents: A Retrospective Study from Saudi Arabia.Medicina (Kaunas, Lithuania) · 2025Article
- Genetic Crosstalk Between Type 1 Diabetes and Sjögren's Syndrome: A Systematic Exploration of Risk Genes and Common Pathways.Journal of cellular and molecular medicine · 2025Article
- Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study.Nature communications · 2025Article
- Assessing genetic and environmental components for pterygium: a nationwide study in Taiwan.Scientific reports · 2024Article
- Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes.Genetic epidemiology · 2023Article
- Family coaggregation of type 1 diabetes mellitus, major depressive disorder, attention-deficiency hyperactivity disorder and autism spectrum disorder in affected families: a nationwide study.Acta diabetologica · 2023Article
- The missing heritability in type 1 diabetes.Diabetes, obesity & metabolism · 2022Review
- Data Resource Profile: The Manitoba Multigenerational Cohort.International journal of epidemiology · 2022Article
- Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.Frontiers in immunology · 2022Review
- Chronic Inflammatory Diseases - Diabetes Mellitus, Rheumatoid Arthritis, Coeliac Disease, Crohn's Disease, and Ulcerative Colitis Among the Offspring of Affected Parents: A Danish Population-Based Registry Study.Clinical epidemiology · 2021Article
- Familial Coaggregation of Asthma and Type 1 Diabetes in Children.JAMA network open · 2020Article
- Heritability and complex segregation analysis of naturally-occurring diabetes in Australian Terrier Dogs.PloS one · 2020Article
- Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine.Endocrine reviews · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks. PATIENTS AND
methodsThis population-based study used the Taiwan National Health Insurance database to reconstruct family structure and identify people with T1D and other chronic diseases between 1999 and 2015. Relative risks (RRs) for T1D and other chronic diseases and heritability of T1D were estimated. Heritability was estimated using the polygenic liability model.
resultsValidation of family structure found the positive predictive value to be 98.7% for maternal links and 98.6% for paternal links. Having an affected twin, first-degree relative, or spouse was associated with an adjusted RR (95% CI) of 553.66 (427.59-716.89), 32.49 (28.66-36.84), and 2.17 (0.31-15.40) for T1D, respectively. Based on the polygenic liability model, heritability, shared and non-shared contributions to T1D, and variances were 66.50%, 10.86%, and 22.64%, respectively. A family history of T1D was associated with an RR (95% CI) of 1.51 (1.20-1.89) for rheumatoid arthritis, 1.66 (1.21-2.26) for Sjögren's syndrome, 1.48 (1.09-2.01) for systemic lupus erythematosus, 1.24 (1.14-1.35) for simple goiter, 1.16 (1.04-1.31) for non-toxic nodular goiter, 1.61 (1.49-1.74) for thyrotoxicosis, 1.78 (1.57-2.01) for acquired hypothyroidism, 1.66 (1.40-1.98) for thyroiditis, and 1.15 (0.97-1.37) for epilepsy.
conclusionThese data highlight the importance of the genetic contribution to T1D and confirm the coaggregation of autoimmune and metabolic diseases with T1D.
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