Evidence map›Paper›PMID 30349386›Full record

ArticleCancer management and research2018

Yan Chen, Lin Zhang, Lei Liu, Shixiu Sun, Xuyang Zhao, Yueyuan Wang, Yujie Zhang, Jun Du, Luo Gu

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  3. RUNX1 promotes NSCLC progression by ACP5/SMAD3-mediated M2 macrophage polarization.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  4. Transcriptomic analysis ofFrontiers in oncology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yan ChenDepartment of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Lin ZhangDepartment of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Lei LiuDepartment of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Shixiu SunDepartment of Physiology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Xuyang ZhaoDepartment of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Yueyuan WangDepartment of Physiology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Yujie ZhangDepartment of Physiology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Jun DuDepartment of Physiology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Luo GuDepartment of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China, lgu@nimu.edu.cn.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRunt-related transcription factor 1 (RUNX1), an essential regulator of hematopoiesis, is overexpressed in patients with nonsmall-cell lung cancer (NSCLC) and is correlated with enhanced metastatic ability. Ras-interacting protein 1 ( MATERIALS AND

methodsRasip1 and RUNX1 expressions were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting in NSCLC cells lines. A549 and H1299 cells were transfected with plasmids or interfering RNA (siRNA) to upregulate or downregulate the expression of Rasip1 and RUNX1. Cell motility was assessed by transwell and wound-healing assay. Location of Rasip1 and RUNX1 was detected via immunofluorescence. Meanwhile, chromatin immunoprecipitation was done using an anti-RUNX1 antibody.

resultsIn this study, we showed that ectopic expression or knockdown of RUNX1 resulted in a significant increase or reduction in Rasip1 expression, respectively. RUNX1 bound directly to a specific DNA sequence within

conclusionOur data indicated that

Indexed as

EGFmigrationnonsmall-cell lung cancerRasip1RUNX1

Identifiers

PMID30349386
PMCPMC6190810
OpenAlexW2896961731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.