ArticleCancer management and research2018
Importance of tumor size at diagnosis as a prognostic factor for hepatocellular carcinoma survival: a population-based study.
Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-surgery strategy versus hepatectomy in hepatocellular carcinoma patients with complete response after conversion therapy: a meta-analysis.World journal of surgical oncology · 2024Pooled it
- Comparative analysis of radiomics and deep-learning algorithms for survival prediction in hepatocellular carcinoma.Scientific reports · 2024Trial
- Quantitative analysis of enhanced CT in predicting microvascular invasion and pathological grading of hepatocellular carcinoma.European radiology · 2026Article
- Dose Is a Critical Factor Affecting Treatment Volumes for Integrated Nanosecond Pulse Irreversible Electroporation (INSPIRE).IEEE transactions on bio-medical engineering · 2026Article
- Combined hematology, tumor morphology, and magnetic resonance imaging for predicting microvascular invasion in hepatocellular carcinoma: a clinical study.Quantitative imaging in medicine and surgery · 2026Article
- Article
- A 7-cm inflection point: nonlinear association between maximum tumor diameter and capsular invasion risk after primary liver cancer resection.BMC gastroenterology · 2026Article
- Tumor index predicts recurrences of patients with pathological stage Ⅰ gastric cancer after radical surgical resection.BMC cancer · 2025Article
- Prognostic and predictive imaging markers of hepatocellular carcinoma: a pictorial essay.Insights into imaging · 2025Article
- Review
- Association between single nucleotide polymorphisms in PNPLA3, TM6SF2 and MBOAT7 genes and markers of cancer aggressiveness in a Sri Lankan NASH-related HCC cohort.BMC gastroenterology · 2025Article
- Seizing tumor factors for mortality and survival outcomes following liver resection in Indonesia's hepatocellular carcinoma patients.Annals of hepato-biliary-pancreatic surgery · 2025Article
- Leveraging weak complementary labels enhances semantic segmentation of hepatocellular carcinoma and intrahepatic cholangiocarcinoma.Scientific reports · 2024Article
- Electrochemotherapy and Calcium Electroporation on Hepatocellular Carcinoma Cells: An In-Vitro Investigation.Cardiovascular and interventional radiology · 2024Article
- Virtual Needle Insertion with Enhanced Haptic Feedback for Guidance and Needle-Tissue Interaction Forces.Sensors (Basel, Switzerland) · 2024Article
- Surgical resection for hepatocellular carcinoma: a single-centre's one decade of experience.Annals of medicine and surgery (2012) · 2024Article
- Article
- Nomogram for predicting overall survival in patients with large (>5 cm) hepatocellular carcinoma based on real-world practice.Journal of liver cancer · 2023Article
- Optimal treatment for small HCC (<3 cm): Resection, liver transplantation, or locoregional therapy?JHEP reports : innovation in hepatology · 2023Review
- FOS-Like Antigen 1 Expression Was Associated With Survival of Hepatocellular Carcinoma Patients.World journal of oncology · 2023Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe effects of hepatocellular carcinoma (HCC) tumor size on clinical presentation and treatment selection and its role as a prognostic factor remain unclear. The present study is a comprehensive analysis of the clinical correlation between tumor size at diagnosis and pathological grades, clinical staging, disparities of treatment, and survival of patients with HCC. MATERIALS AND
methodsPatients with HCC were separated into groups according to tumor size as follows: 0.1-2.0, 2.1-5.0, 5.1-10.0, and 10.1-20.0 cm. Logistic regression analysis was used to determine the relationship between tumor size at diagnosis and pathological grade, Surveillance, Epidemiology, and End Results (SEER) historic stage A, and treatment selection. The survival of HCC patients stratified by tumor size was estimated by Kaplan-Meier and 5-year survival analyses using the log-rank test. Multivariable analysis of overall survival was performed using the Cox proportional hazards model. Tumor size at diagnosis was an independent risk factor of pathological grade, and SEER historic stage A was revealed by logistic regression analysis.
resultsThe 5-year survival rate was 21.9% vs 14.3% vs 9.2% vs 7.7% for all HCC patients and 31.2% vs 23.6% vs 20.3% vs 15.5% for patients who underwent surgery with tumor sizes of 0.1-2.0 vs 2.1-5.0 and 5.1-10.0 vs 10.1-20.0 cm, respectively; multivariable Cox regression analysis identified tumor size at diagnosis as an independent predictor of survival risk with HR of 1.00 vs 1.66 vs 2.92 vs 3.67, respectively.
conclusionTumor size at diagnosis could be used as an independent risk predictor associated with histological grade, stage, selection of surgery, and survival in HCC.
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