ArticleJournal of pain research2018
Open field and a behavior score in PNT model for neuropathic pain in pigs.
Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Open Field Test as a Tool for Behaviour Analysis in Pigs: Recommendations for Set-Up Standardization - A Systematic Review.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2023Pooled it
- Pooled it
- Longitudinal multimodal assessment of neuropathy in a porcine neuritis model.Journal of neuroscience methods · 2026Article
- What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain.Bone research · 2025Review
- Part I: understanding pain in pigs-basic knowledge about pain assessment, measures and therapy.Porcine health management · 2025Review
- Intradermally injected abobotulinumtoxinA administered preemptively before surgery alleviates post-surgical pain and normalizes behavior in a translational animal model.Scientific reports · 2025Article
- Spared ulnar nerve injury results in increased layer III-VI excitability in the pig somatosensory cortex.Lab animal · 2024Article
- Non-invasive central nervous system assessment of a porcine model of neuropathic pain demonstrates increased latency of somatosensory-evoked potentials.Journal of neuroscience methods · 2023Article
- On determining the mechanical nociceptive threshold in pigs: a reliability study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.Scientific reports · 2022Article
- Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Pharmacokinetics of Panaxynol in Mice.Journal of cancer science and clinical therapeutics · 2020Article
- Intrathecal Oxytocin Improves Spontaneous Behavior and Reduces Mechanical Hypersensitivity in a Rat Model of Postoperative Pain.Frontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRodent models are frequently used in the research of pain and continue to provide valuable data on the mechanisms driving pain, although they are criticized due to limited translational ability to human conditions. Previously we have suggested pigs as a model for development of drugs for neuropathic pain. In this study, we investigate the spontaneous behavior of pigs following peripheral neuritis trauma (PNT)-induced neuropathic pain.
methodsA computerized monitoring system was used to evaluate the changes in open field test in addition to applying a composite behavior scoring system. The data suggest that the PNT operation did not affect the animal's ability to walk as the total distance walked by PNT animals was not significantly different from the total distance walked by sham-operated animals. However, PNT animals expressed a significant change in the pattern of walking. This effect was unrelated to the time that the animals spent in the open field. Following treatment with different drugs (morphine, buprenorphine, or gabapentin), the walking pattern of the animals in the open field changed in a drug-specific manner. In addition, the detailed behavior score revealed drug-specific changes following treatment.
resultsPharmacokinetic analysis of the drug concentration in blood and cerebrospinal fluid correlated with the behavioral analysis.
conclusionThe data of this study suggest that the open field test together with the detailed behavior score applied in this model are a powerful tool to assess the spontaneous behavior of pigs following PNT-induced neuropathic pain.
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