Evidence map›Paper›PMID 30349268›Full record

ArticleNeuropsychiatric disease and treatment2018

Minocycline as adjunct therapy for a male patient with deficit schizophrenia.

Xiaohua Chen, Zhenzhen Xiong, Zhixiong Li, Yali Yang, Zhanying Zheng, Yonghong Li, Yan Xie, Zhe Li

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  6. Article
  7. Synaptic Elimination in Neurological Disorders.Current neuropharmacology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaohua ChenDepartment of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhenzhen XiongSchool of Nursing, Chengdu Medical College, Chengdu, Sichuan 610083, China.
Zhixiong LiThe Third Department of Clinical Psychology, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
Yali YangThe Second Department of Clinical Psychology, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
Zhanying ZhengThe First Department of Clinical Psychology, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
Yonghong LiThe Sleep Medicine Department, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
Yan XieThe Sleep Medicine Department, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.
Zhe LiMental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China, jay_li@163.com.
Karamay Central Hospital · CNChengdu Medical College · CNSichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiology of schizophrenia may involve increased production of inflammatory cytokines by activated microglia. Minocycline can inhibit activated microglia and may improve secondary negative symptoms and/or cognitive functions when used as adjuvant to antipsychotics. Effects on minocycline on primary and enduring negative symptoms in deficit schizophrenia (DS) are unknown. We present a male patient with a 3-year history of DS. He was treated for 12 weeks with risperidone at a maximal dose of 6 mg per day, then for 10 weeks with olanzapine at 20 mg per day. Symptoms did not improve, and body mass index increased from 20.41 to 22.84 kg/m

Indexed as

adjunct therapydeficit schizophreniaminocycline

Identifiers

PMID30349268
PMCPMC6188198
OpenAlexW2895971715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.