ArticleInternational journal of nanomedicine2018
Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells.
Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Carbon dots derived from natural medicines: Therapeutic advances and challenges.Journal of pharmaceutical analysis · 2026Review
- Self-oxidatively crosslinked sprayable hydrogel for microenvironment remodeling and accelerated healing of recurrent aphthous ulcers.Materials today. Bio · 2026Article
- Ginsenoside Re attenuates homocysteine-induced endothelial cell ferroptosis through upregulation of GPX4/xCT signaling.Experimental and therapeutic medicine · 2026Article
- Bioactive Constituents of Ginseng in Cancer Therapy: Molecular Mechanisms, Translational Potential, and Advanced Delivery Strategies.International journal of biological sciences · 2026Review
- Carbon Dots: Emerging Nanomaterials for Ovarian Cancer Diagnosis and Therapy.Current drug targets · 2026Review
- Recent progress in biowaste-derived carbon dots for cancer theranostics toward a green solution to toxic metal quantum dots.Discover nano · 2025Review
- Anti-lung cancer therapy using nano-assembly particles of traditional Chinese Medicine formula.Materials today. Bio · 2025Article
- Ginseng-Derived Carbon Quantum Dots Enhance Systemic Exposure of Bioactive Ginsenosides and Amplify Energy Metabolism in Mice.Pharmaceutics · 2025Article
- Bioinspired quantum dots: advancing diagnostic and therapeutic strategies in breast cancer.RSC advances · 2025Review
- Carbon dots from purple sweet potato as a promising anti-inflammatory biomaterial for alleviating the LPS-induced inflammation in macrophages.Journal of nanobiotechnology · 2025Article
- Eco-Friendly Synthesized Carbon Dots from Chinese Herbal Medicine: A Review.International journal of nanomedicine · 2025Review
- Application of rare earth elements in dual-modality molecular probes.RSC advances · 2024Review
- Medicinal Plants Derived Green Carbon Dots: Synthesis, Characterization and Their Potential Applications in Cancer Therapy.Asian Pacific journal of cancer prevention : APJCP · 2024Review
- Anticancer activity of quantum size carbon dots: opportunities and challenges.Discover nano · 2024Review
- Cancer Cell Targeting Via Selective Transferrin Receptor Labeling Using Protein-Derived Carbon Dots.ACS omega · 2024Article
- Antimicrobial and Remineralization of Carboxymethyl Chitosan and Xylitol Functionalized Carbon Dots Coating on Orthodontic Brackets.International journal of nanomedicine · 2024Article
- Potential Efficacy of Herbal Medicine-Derived Carbon Dots in the Treatment of Diseases: From Mechanism to Clinic.International journal of nanomedicine · 2023Review
- A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment.Nanotheranostics · 2023Review
- Recent Advances in Nanomaterials of Group XIV Elements of Periodic Table in Breast Cancer Treatment.Pharmaceutics · 2022Review
- Assessing the Environmental Effects Related to Quantum Dot Structure, Function, Synthesis and Exposure.Environmental science. Nano · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluorescent carbon-based nanomaterials have promising properties such as biosensing, cell imaging, tracing and drug delivery. However, carbon dots (CDs) with specific inherent biological functions have not been investigated. Ginsenosides are the components with multiple bioactivities found in plants of the genus MATERIALS AND
methodsIn this study, we prepared a kind of novel photoluminescent CDs from ginsenoside Re by one-step hydrothermal synthesis method. The conventional methods including transmission electron microscopy, Fourier transform infrared spectroscopy, HPLC and fluorescence spectrum were used for characterization of CDs. In vitro anticancer effect was investigated by cytotoxicity assay, flow cytometry and Western blot analysis.
resultsThe as-prepared Re-CDs had an average diameter of 4.6±0.6 nm and excellent luminescent properties. Cellular uptake of Re-CDs was facilitated by their tiny nanosize, with evidence of their bright excitation-dependent fluorescent images. Compared with ginsenoside Re, the Re-CDs showed greater inhibition efficiency of cancer cell proliferation, with lower toxicity to the normal cells. The anticancer activity of Re-CDs was suggested to be associated with the generation of large amount of ROS and the caspase-3 related cell apoptosis.
conclusionHopefully, the dual functional Re-CDs, which could both exhibit bioimaging and anticancer effect, are expected to have great potential in future clinical applications.
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