Evidence map›Paper›PMID 30349237›Full record

ReviewInternational journal of chronic obstructive pulmonary disease

Role of inflammatory cells in airway remodeling in COPD.

Yujie Wang, Jiayan Xu, Yaqi Meng, Ian M Adcock, Xin Yao

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04042519 (The Correlation Research Between the Omega-3 and Omega-6 Inflammatory Metabolites and Stable COPD.), which is not on this map. Cited by 201 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 8 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04042519 completednot on this map

The Correlation Research Between the Omega-3 and Omega-6 Inflammatory Metabolites and Stable COPD.

TypeobservationalSponsorGuangzhou Institute of Respiratory DiseaseRan2016 to 2019Enrolled200ConditionsMetabolomics, Omega 6, Omega 3, COPDArmsLung function test was performed on the subjects with Jaeger lung function instrument of Germany., Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection., Routine blood test
3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 8 syntheses or guidelines pooled it, 365 citations in OpenAlex.

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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Yujie WangDepartment of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, yaoxin@njmu.edu.cn.
Jiayan XuDepartment of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, yaoxin@njmu.edu.cn.
Yaqi MengDepartment of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, yaoxin@njmu.edu.cn.
Ian M AdcockCell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Xin YaoDepartment of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, yaoxin@njmu.edu.cn.
Jiangsu Province Hospital · CNLung Institute · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD. Chronic inflammation in COPD mainly involves the infiltration of neutrophils, macrophages, lymphocytes, and other inflammatory cells into the small airways. The contribution of resident airway structural cells to the inflammatory process is also important in COPD. Airway remodeling consists of detrimental changes in structural tissues and cells including airway wall thickening, epithelial metaplasia, goblet cell hypertrophy, and smooth muscle hyperplasia. Persistent airway inflammation might contribute to airway remodeling and small airway obstruction. However, the underlying mechanisms remain unclear. In this review, we will provide an overview of recent insights into the role of major immunoinflammatory cells in COPD airway remodeling.

Indexed as

Pulmonary Disease, Chronic ObstructiveAirway ObstructionAirway RemodelingHumansInflammationLeukocytesMacrophages, AlveolarNeutrophil Infiltrationairway inflammationairway remodelingCOPD

Identifiers

PMID30349237
PMCPMC6190811
OpenAlexW2895954347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.