ArticleScientific reports2018
Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Wheat Flour Intake Promotes Weight Gain and Metabolic Changes in Mice.Molecular nutrition & food research · 2026Article
- High-resolution fecal pharmacokinetic modeling in mice with orally administered antibiotics.Scientific reports · 2025Article
- Comparative analysis of dietary fiber impact on bile acid metabolism and gut microbiota composition in mice.Npj gut and liver · 2025Article
- The Consumption of the Fibrous Fraction ofFoods (Basel, Switzerland) · 2024Article
- Impact of Plant-Based Dietary Fibers on Metabolic Homeostasis in High-Fat Diet Mice via Alterations in the Gut Microbiota and Metabolites.The Journal of nutrition · 2024Article
- Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches.Pharmacology & therapeutics · 2024Review
- Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma.Frontiers in nutrition · 2024Article
- Resident gut microbiota community determines the efficacy of soluble fiber in reducing adiposity.Frontiers in microbiology · 2024Article
- Gut physiology meets microbiome science.Gut microbiome (Cambridge, England) · 2023Review
- Pectin in Metabolic Liver Disease.Nutrients · 2022Review
- Prebiotic supplementation modulates selective effects of stress on behavior and brain metabolome in aged mice.Neurobiology of stress · 2022Article
- Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.American journal of physiology. Endocrinology and metabolism · 2022Article
- The MicroalgaeNutrients · 2022Article
- Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice.Molecular metabolism · 2022Article
- Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota.Nutrients · 2021Review
- Low Dietary Fiber Intake Links Development of Obesity and Lupus Pathogenesis.Frontiers in immunology · 2021Article
- Cage bedding modifies metabolic and gut microbiota profiles in mouse studies applying dietary restriction.Scientific reports · 2020Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary fibers (DF) can prevent obesity in rodents fed a high-fat diet (HFD). Their mode of action is not fully elucidated, but the gut microbiota have been implicated. This study aimed to identify the effects of seven dietary fibers (barley beta-glucan, apple pectin, inulin, inulin acetate ester, inulin propionate ester, inulin butyrate ester or a combination of inulin propionate ester and inulin butyrate ester) effective in preventing diet-induced obesity and links to differences in cecal bacteria and host gene expression. Mice (n = 12) were fed either a low-fat diet (LFD), HFD or a HFD supplemented with the DFs, barley beta-glucan, apple pectin, inulin, inulin acetate ester, inulin propionate ester, inulin butyrate ester or a combination of inulin propionate ester and inulin butyrate ester for 8 weeks. Cecal bacteria were determined by Illumina MiSeq sequencing of 16S rRNA gene amplicons. Host responses, body composition, metabolic markers and gene transcription (cecum and liver) were assessed post intervention. HFD mice showed increased adiposity, while all of the DFs prevented weight gain. DF specific differences in cecal bacteria were observed. Results indicate that diverse DFs prevent weight gain on a HFD, despite giving rise to different cecal bacteria profiles. Conversely, common host responses to dietary fiber observed are predicted to be important in improving barrier function and genome stability in the gut, maintaining energy homeostasis and reducing HFD induced inflammatory responses in the liver.
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