Evidence map›Paper›PMID 30349106›Full record

ArticleNature neuroscience2018

A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex.

Sarah J Marzi, Szi Kay Leung, Teodora Ribarska, Eilis Hannon, Adam R Smith, Ehsan Pishva, Jeremie Poschmann, Karen Moore, Claire Troakes, Safa Al-Sarraj and 5 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 2 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 2 syntheses or guidelines pooled it, 233 citations in OpenAlex.

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  8. Blood DNA Methylation Predicts Long-Term Risk of Dementia in Prospective Cohorts.medRxiv : the preprint server for health sciences · 2026
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Sarah J MarziInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Szi Kay LeungUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Teodora RibarskaOslo University Hospital, Oslo, Norway.
Eilis HannonUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Adam R SmithUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0001-6495-2711
Ehsan PishvaUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Jeremie PoschmannUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Karen MooreUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Claire TroakesInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1790-7376
Safa Al-SarrajInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Stephan BeckUCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0001-5290-2151
Stuart NewmanUniversity of Essex, Colchester, UK.
Katie LunnonUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Leonard C SchalkwykUniversity of Essex, Colchester, UK.
Jonathan MillUniversity of Exeter Medical School, University of Exeter, Exeter, UK. J.Mill@exeter.ac.uk.ORCID http://orcid.org/0000-0003-1115-3224
University of Exeter · GBKing's College London · GBUniversity of Essex · GBCRUK Lung Cancer Centre of Excellence · GBInserm · FROslo University Hospital · NOQueen Mary University of London · GB

Funding

Medical Research Council MR/L016397/1Medical Research Council MR/M008924/1
6 · The paper itself

Abstract

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel sequencing. We observed widespread acetylomic variation associated with AD neuropathology, identifying 4,162 differential peaks (false discovery rate < 0.05) between AD cases and controls. Differentially acetylated peaks were enriched in disease-related biological pathways and included regions annotated to genes involved in the progression of amyloid-β and tau pathology (for example, APP, PSEN1, PSEN2, and MAPT), as well as regions containing variants associated with sporadic late-onset AD. Partitioned heritability analysis highlighted a highly significant enrichment of AD risk variants in entorhinal cortex H3K27ac peak regions. AD-associated variable H3K27ac was associated with transcriptional variation at proximal genes including CR1, GPR22, KMO, PIM3, PSEN1, and RGCC. In addition to identifying molecular pathways associated with AD neuropathology, we present a framework for genome-wide studies of histone modifications in complex disease.

Indexed as

AcetylationAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-Protein PrecursorEntorhinal CortexFemaleGenetic Predisposition to DiseaseHistonesHumansMaleMiddle Agedtau ProteinsAmyloid beta-Protein PrecursorHistonestau Proteins

Identifiers

PMID30349106
OpenAlexW2896025743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.