ArticleNature communications2018
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- The role of E3 ubiquitin ligases in selective types of macroautophagy.EMBO reports · 2026Review
- Activation of pro-survival autophagy by a small molecule promoting p62 oligomerization.The Journal of biological chemistry · 2026Article
- Molecular Docking and Simulation-Based Exploration of Niclosamide as a Potential Inhibitor of the p62 ZZ Domain.Biology · 2026Article
- Reconstitution of protein arginylation pathways in bacteria for robust identification and quantification.Communications biology · 2026Article
- Arsenic disrupts autophagosome-lysosome fusion in a zinc dependent manner across multiple human skin and lung cells lines.Archives of toxicology · 2026Article
- Targeted delivery of glucocerebrosidase to lysosomes: The LYSOTAC (LYSOsome-TArgeting Chimera) technology.Asian journal of pharmaceutical sciences · 2026Article
- Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin.Nature communications · 2025Article
- Arginyltransferase1 drives a mitochondria-dependent program to induce cell death.Cell death & disease · 2025Article
- M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.Molecular cancer · 2025Article
- Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome.Redox biology · 2025Article
- Semaglutide enhances PINK1/Parkin‑dependent mitophagy in hypoxia/reoxygenation‑induced cardiomyocyte injury.Molecular medicine reports · 2025Article
- CDC20-Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Targeting mitophagy in diabetic retinopathy: novel insights into SQSTM1/BNIP3L pathway regulated by luteolin.Frontiers in pharmacology · 2025Article
- Autophagy in mycobacterial infections: molecular mechanisms, host-pathogen interactions, and therapeutic opportunities.Frontiers in cellular and infection microbiology · 2025Review
- HACE1 as a bridge between oxidative stress and autophagy.Frontiers in immunology · 2025Review
- Article
- Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function.Nature communications · 2024Article
- Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma.Haematologica · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
15 authors at 5 institutions in 3 countries.
Yi ZhangDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0001-8170-9983
Su Ran MunProtein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.ORCID http://orcid.org/0000-0002-5320-1135
Juan F LinaresCancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
JaeWoo AhnDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Christina G TowersDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Chang Hoon JiProtein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea.
Brent E FitzwalterDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Michael R HoldenDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Wenyi MiCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.ORCID http://orcid.org/0000-0002-7453-051X
Xiaobing ShiCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.ORCID http://orcid.org/0000-0001-5242-8189
Jorge MoscatCancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Andrew ThorburnDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Maria T Diaz-MecoCancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Yong Tae KwonProtein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. yok5@snu.ac.kr.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. tatiana.kutateladze@ucdenver.edu.ORCID http://orcid.org/0000-0001-7375-6990
University of Colorado Denver · USSanford Burnham Prebys Medical Discovery Institute · USSeoul National University · KRVan Andel Institute · USNational University College · PR
Funding
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1MRole of autophagy in tumor cell deathR01CA150925 · NCI · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2010 to 2024
$5.5MRole of p62/SQSTM1 in obesity-induced liver cancerR01CA211794 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL, MOSCAT, JORGE · 2017 to 2021
$3.6MTraining Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5MRole of p62 in metabolic reprograming of the tumor stroma in prostate cancerR01CA218254 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DIAZ MECO CONDE, MARIA TERESA, METALLO, CHRISTIAN MICHAEL · 2017 to 2021
$2.6MTherapeutic targeting of autophagy-dependent cancerR01CA190170 · NCI · UNIVERSITY OF COLORADO DENVER · PI GUSTAFSON, DANIEL L, THORBURN, ANDREW M · 2015 to 2019
$2.5MThe p62/MEKK3 complex in mTORC1 activationR01CA192642 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI DIAZ MECO CONDE, MARIA TERESA · 2015 to 2019
$2.2MControl of stellate cells-driven liver cancer by the p62/NBR1 adaptersR01DK108743 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCAT, JORGE · 2016 to 2020
$2.2MRole of GAS41 in Human CancerR01CA204020 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI SHI, XIAOBING · 2016 to 2020
$2.0MMolecular analysis of methylated p53R01GM101664 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2013 to 2016
$1.7MEpigenetic regulation by PHF1R01GM106416 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.5MMolecular mechanism of chromatin targeting by BRPF1R01GM100907 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.4MNCI NIH HHS R01 CA150925NCI NIH HHS R01 CA190170NCI NIH HHS R01 CA192642NCI NIH HHS R01 CA204020NCI NIH HHS R01 CA211794NCI NIH HHS R01 CA218254NCI NIH HHS T32 CA190216NIDDK NIH HHS R01 DK108743NIGMS NIH HHS R01 GM100907NIGMS NIH HHS R01 GM101664NIGMS NIH HHS R01 GM106416NIGMS NIH HHS R01 GM125195NIGMS NIH HHS T32 GM007635U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA150925U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA190170U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA192642U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA204020U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA211794U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA218254U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM100907U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM101664U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM106416
Abstract
Autophagic receptor p62 is a critical mediator of cell detoxification, stress response, and metabolic programs and is commonly deregulated in human diseases. The diverse functions of p62 arise from its ability to interact with a large set of ligands, such as arginylated (Nt-R) substrates. Here, we describe the structural mechanism for selective recognition of Nt-R by the ZZ domain of p62 (p62
Indexed as
AutophagyCell LineCrystallography, X-RayFlow CytometryHEK293 CellsHumansImmunohistochemistryMagnetic Resonance SpectroscopyMechanistic Target of Rapamycin Complex 1Protein BindingSequestosome-1 ProteinSignal TransductionSpectrometry, FluorescenceMechanistic Target of Rapamycin Complex 1Sequestosome-1 ProteinSQSTM1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.