Evidence map›Paper›PMID 30348978›Full record

ArticleTranslational psychiatry2018

Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I.

Inga H Deakin, Beata R Godlewska, Mary A Walker, Guo-Jen Huang, Markus H Schwab, Klaus-Armin Nave, Amanda J Law, Paul J Harrison

Abstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Inga H DeakinDepartment of Psychiatry, University of Oxford, Oxford, UK.
Beata R GodlewskaDepartment of Psychiatry, University of Oxford, Oxford, UK.
Mary A WalkerDepartment of Psychiatry, University of Oxford, Oxford, UK.
Guo-Jen HuangWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Markus H SchwabDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany.
Klaus-Armin NaveDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany.
Amanda J LawDepartment of Psychiatry, University of Oxford, Oxford, UK.
Paul J HarrisonDepartment of Psychiatry, University of Oxford, Oxford, UK. paul.harrison@psych.ox.ac.uk.ORCID http://orcid.org/0000-0002-6719-1126

Funding

Medical Research Council G0500180Wellcome Trust
6 · The paper itself

Abstract

Transgenic mice overexpressing the type I isoform of neuregulin 1 (Nrg1; NRG1) have alterations in hippocampal gamma oscillations and an age-emergent deficit in hippocampus-dependent spatial working memory. Here, we examined the molecular and morphological correlates of these findings. Microarrays showed over 100 hippocampal transcripts differentially expressed in Nrg1

Indexed as

Gene ExpressionAnimalsEncephalitisFemaleHippocampusMaleMice, Inbred C57BLMice, TransgenicNeuregulin-1Protein IsoformsSignal TransductionTranscriptomeUp-RegulationNeuregulin-1Nrg1 protein, mouseProtein Isoforms

Identifiers

PMID30348978
PMCPMC6197224

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.